Detailed information of TA system TA075139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1054804..1055448
• Replicon: chromosome
• Accession: NZ_CP020562
• Organism: Halomonas sp. GT

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: B6A39_RS04935
• Protein ID: WP_083001961.1
• Coordinates: 1055266..1055448 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: B6A39_RS04930
• Protein ID: WP_083001959.1
• Coordinates: 1054804..1055223 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6A39_RS04905	1050505..1050855	+	351	WP_083001949.1	hypothetical protein	-
B6A39_RS18880	1051134..1051289	+	156	WP_156886198.1	hypothetical protein	-
B6A39_RS04910	1051466..1052326	+	861	WP_156886199.1	hypothetical protein	-
B6A39_RS04915	1052389..1052820	-	432	WP_083001953.1	hypothetical protein	-
B6A39_RS04920	1052839..1053336	-	498	WP_083001955.1	hypothetical protein	-
B6A39_RS04925	1053333..1054139	-	807	WP_083001957.1	TIGR04255 family protein	-
B6A39_RS04930	1054804..1055223	-	420	WP_083001959.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B6A39_RS04935	1055266..1055448	-	183	WP_083001961.1	type II toxin-antitoxin system HicA family toxin	Toxin
B6A39_RS04940	1055535..1056515	-	981	WP_083001964.1	phage late control D family protein	-
B6A39_RS04945	1056512..1056955	-	444	WP_083001966.1	phage tail protein	-
B6A39_RS04950	1056966..1059611	-	2646	WP_083001968.1	hypothetical protein	-
B6A39_RS04955	1059658..1059783	-	126	WP_083001970.1	GpE family phage tail protein	-
B6A39_RS04960	1059816..1060166	-	351	WP_083001972.1	phage tail assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1039526..1079926	40400

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6641.78 Da
• Isoelectric Point: 11.2210

>T75139 WP_083001961.1 NZ_CP020562:c1055448-1055266 [Halomonas sp. GT]
VNSRALIKELEADGWELVRVKGSHHHFRHPTKPGTVTVPHPKKDLKTGLVKGIRKSAGLL

Nucleotide

• Length: 183 bp

>T75139 NZ_CP020562:c1055448-1055266 [Halomonas sp. GT]
GTGAATAGCAGAGCACTGATCAAGGAACTGGAAGCGGATGGCTGGGAGTTAGTGAGAGTCAAAGGCAGCCACCACCATTT
CAGGCACCCTACTAAGCCAGGCACAGTGACCGTGCCACATCCCAAAAAGGATTTGAAAACAGGGCTAGTAAAGGGAATCA
GAAAAAGCGCCGGCCTCTTATGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15241.20 Da
• Isoelectric Point: 4.3899

>AT75139 WP_083001959.1 NZ_CP020562:c1055223-1054804 [Halomonas sp. GT]
MLFPIAIERGDEQHAYGVAVPDLPGCHSAGDTFEEAMVNAKEAIEGWLEVAVDYGDPIPEATSIEHHMDNPDFEGWIWAV
IDIDLTPYLGKSHKINVTLPDLLVKQIDDFVASHPGDKTRSGFLSRVAMAELAKARKSA

Nucleotide

• Length: 420 bp

>AT75139 NZ_CP020562:c1055223-1054804 [Halomonas sp. GT]
ATGTTGTTTCCCATTGCAATTGAACGCGGCGACGAACAACACGCCTACGGCGTGGCGGTGCCTGATTTGCCCGGCTGCCA
TTCAGCAGGCGATACCTTTGAAGAAGCGATGGTCAACGCCAAGGAAGCCATTGAAGGCTGGCTAGAAGTCGCCGTGGACT
ACGGCGACCCGATTCCTGAAGCAACGTCTATCGAACACCACATGGATAACCCCGATTTTGAAGGCTGGATCTGGGCCGTG
ATCGATATTGACCTAACCCCCTACCTGGGCAAAAGCCACAAAATCAACGTCACGTTGCCAGACCTACTGGTGAAACAGAT
TGACGACTTTGTGGCCAGCCACCCAGGGGATAAAACGCGTAGCGGATTCCTCTCGCGGGTTGCCATGGCAGAACTGGCCA
AAGCACGTAAAAGCGCATAA