Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4199148..4200408 Replicon chromosome
Accession NZ_CP020560
Organism Pseudomonas aeruginosa strain CR1

Toxin (Protein)


Gene name - Uniprot ID A0A424XGP4
Locus tag B7D75_RS19890 Protein ID WP_074197528.1
Coordinates 4199148..4199903 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2R3IR82
Locus tag B7D75_RS19895 Protein ID WP_003157715.1
Coordinates 4200040..4200408 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D75_RS19880 4196463..4197014 + 552 WP_012076759.1 AAA family ATPase -
B7D75_RS19885 4197018..4198378 - 1361 Protein_3848 DNA recombination protein RmuC -
B7D75_RS19890 4199148..4199903 - 756 WP_074197528.1 RES family NAD+ phosphorylase Toxin
B7D75_RS19895 4200040..4200408 - 369 WP_003157715.1 DUF2384 domain-containing protein Antitoxin
B7D75_RS19900 4200482..4201768 - 1287 WP_107114350.1 FAD-binding oxidoreductase -
B7D75_RS19905 4201832..4203325 - 1494 WP_043099249.1 aldehyde dehydrogenase family protein -
B7D75_RS19910 4203499..4203975 + 477 WP_033998987.1 elongation factor GreAB -
B7D75_RS19915 4203978..4204259 - 282 WP_034079448.1 zinc ribbon domain-containing protein -
B7D75_RS19920 4204412..4205398 - 987 WP_079977066.1 nitronate monooxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(64-205)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-67)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28325.53 Da        Isoelectric Point: 8.3280

>T75134 WP_074197528.1 NZ_CP020560:c4199903-4199148 [Pseudomonas aeruginosa]
VSEIWRLCAGEKQVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPLPESAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPGLFYAALKLETAMAEGAYYRCVLWSGMAVPPPSGRILSEHASFEAAWKVERGVRLQEPPFSDYERALTDTA
DYRVAQELGSAMRGAGVQAFEYRSARCPQRGCNVALFTPRAFIEKRPRNLTPWLCETTASYVAFKPAHVPGSPKVFAREL
FLVDGRLPQPA

Download         Length: 756 bp

>T75134 NZ_CP020560:c4199903-4199148 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGCCTCTGCGCAGGCGAGAAGCAGGTCCGGCCGCTGCAAGGGCGGCTGGTGCGGCTGGTGGAGAG
CCAGGAGCAGGTGGCGACTCTGCAACTGGTGGATACCCTCGAGGAGCAGGCGTTGCTCGAGGAGTTGCTGGAGTCCAGCA
AGCCGCCGCTGCCGGAAAGTGCCGAGCCGCTGCATTACCTGTTGAAGACGCCGTTCCGCTATCCGCCCTTGCGCTGGGGC
TCGCGCTTCGGTCGCCGGCATGAGCCAGGCCTGTTCTATGCCGCGCTGAAACTGGAGACAGCGATGGCCGAGGGCGCCTA
TTACCGTTGCGTCCTGTGGAGCGGCATGGCGGTGCCGCCGCCCAGTGGGCGGATCCTTTCCGAGCACGCCTCGTTCGAGG
CGGCCTGGAAGGTGGAGCGGGGCGTTCGCCTGCAGGAACCGCCTTTCTCCGACTACGAGCGCGCGCTGACCGATACCGCC
GACTACCGAGTCGCCCAGGAGCTGGGTAGTGCCATGCGCGGCGCCGGTGTACAGGCATTCGAGTATCGTTCGGCGCGTTG
CCCGCAGCGTGGCTGCAATGTCGCCCTGTTTACGCCGCGGGCCTTCATCGAGAAACGTCCGCGCAACCTGACCCCATGGC
TGTGCGAAACCACCGCCAGCTATGTGGCGTTCAAGCCTGCGCACGTGCCGGGCTCGCCGAAGGTGTTCGCTCGCGAACTG
TTCCTGGTGGACGGCCGCCTGCCCCAGCCGGCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13353.60 Da        Isoelectric Point: 9.9874

>AT75134 WP_003157715.1 NZ_CP020560:c4200408-4200040 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGILGVDRSAISRWKSQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDLRHFMRTPNHHLGGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT75134 NZ_CP020560:c4200408-4200040 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGCCCCAGTGCCGATGCCGTCCTGGCCAAGGCGGTGCTGGCCGCGCGCGAGCAGCTGGG
CCTGACGCAACTCGAACTGGCCGGGATCCTCGGCGTCGACCGCAGCGCCATCAGCCGCTGGAAGAGCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAACTGGCCCTGCTGCTCGTGCGGGTCTACCGCGCGCTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACCTGCGTCATTTCATGCGCACGCCCAACCATCACCTGGGCGGGGAGCCCCTGGCGCTGATGGGACAGGTACAGGG
CCTGGTGCATGTACTGGAGTACCTCGACGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A424XGP4

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3IR82

References