Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 4199148..4200408 | Replicon | chromosome |
| Accession | NZ_CP020560 | ||
| Organism | Pseudomonas aeruginosa strain CR1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A424XGP4 |
| Locus tag | B7D75_RS19890 | Protein ID | WP_074197528.1 |
| Coordinates | 4199148..4199903 (-) | Length | 252 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2R3IR82 |
| Locus tag | B7D75_RS19895 | Protein ID | WP_003157715.1 |
| Coordinates | 4200040..4200408 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B7D75_RS19880 | 4196463..4197014 | + | 552 | WP_012076759.1 | AAA family ATPase | - |
| B7D75_RS19885 | 4197018..4198378 | - | 1361 | Protein_3848 | DNA recombination protein RmuC | - |
| B7D75_RS19890 | 4199148..4199903 | - | 756 | WP_074197528.1 | RES family NAD+ phosphorylase | Toxin |
| B7D75_RS19895 | 4200040..4200408 | - | 369 | WP_003157715.1 | DUF2384 domain-containing protein | Antitoxin |
| B7D75_RS19900 | 4200482..4201768 | - | 1287 | WP_107114350.1 | FAD-binding oxidoreductase | - |
| B7D75_RS19905 | 4201832..4203325 | - | 1494 | WP_043099249.1 | aldehyde dehydrogenase family protein | - |
| B7D75_RS19910 | 4203499..4203975 | + | 477 | WP_033998987.1 | elongation factor GreAB | - |
| B7D75_RS19915 | 4203978..4204259 | - | 282 | WP_034079448.1 | zinc ribbon domain-containing protein | - |
| B7D75_RS19920 | 4204412..4205398 | - | 987 | WP_079977066.1 | nitronate monooxygenase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28325.53 Da Isoelectric Point: 8.3280
>T75134 WP_074197528.1 NZ_CP020560:c4199903-4199148 [Pseudomonas aeruginosa]
VSEIWRLCAGEKQVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPLPESAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPGLFYAALKLETAMAEGAYYRCVLWSGMAVPPPSGRILSEHASFEAAWKVERGVRLQEPPFSDYERALTDTA
DYRVAQELGSAMRGAGVQAFEYRSARCPQRGCNVALFTPRAFIEKRPRNLTPWLCETTASYVAFKPAHVPGSPKVFAREL
FLVDGRLPQPA
VSEIWRLCAGEKQVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPLPESAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPGLFYAALKLETAMAEGAYYRCVLWSGMAVPPPSGRILSEHASFEAAWKVERGVRLQEPPFSDYERALTDTA
DYRVAQELGSAMRGAGVQAFEYRSARCPQRGCNVALFTPRAFIEKRPRNLTPWLCETTASYVAFKPAHVPGSPKVFAREL
FLVDGRLPQPA
Download Length: 756 bp
>T75134 NZ_CP020560:c4199903-4199148 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGCCTCTGCGCAGGCGAGAAGCAGGTCCGGCCGCTGCAAGGGCGGCTGGTGCGGCTGGTGGAGAG
CCAGGAGCAGGTGGCGACTCTGCAACTGGTGGATACCCTCGAGGAGCAGGCGTTGCTCGAGGAGTTGCTGGAGTCCAGCA
AGCCGCCGCTGCCGGAAAGTGCCGAGCCGCTGCATTACCTGTTGAAGACGCCGTTCCGCTATCCGCCCTTGCGCTGGGGC
TCGCGCTTCGGTCGCCGGCATGAGCCAGGCCTGTTCTATGCCGCGCTGAAACTGGAGACAGCGATGGCCGAGGGCGCCTA
TTACCGTTGCGTCCTGTGGAGCGGCATGGCGGTGCCGCCGCCCAGTGGGCGGATCCTTTCCGAGCACGCCTCGTTCGAGG
CGGCCTGGAAGGTGGAGCGGGGCGTTCGCCTGCAGGAACCGCCTTTCTCCGACTACGAGCGCGCGCTGACCGATACCGCC
GACTACCGAGTCGCCCAGGAGCTGGGTAGTGCCATGCGCGGCGCCGGTGTACAGGCATTCGAGTATCGTTCGGCGCGTTG
CCCGCAGCGTGGCTGCAATGTCGCCCTGTTTACGCCGCGGGCCTTCATCGAGAAACGTCCGCGCAACCTGACCCCATGGC
TGTGCGAAACCACCGCCAGCTATGTGGCGTTCAAGCCTGCGCACGTGCCGGGCTCGCCGAAGGTGTTCGCTCGCGAACTG
TTCCTGGTGGACGGCCGCCTGCCCCAGCCGGCATGA
GTGAGCGAGATCTGGCGCCTCTGCGCAGGCGAGAAGCAGGTCCGGCCGCTGCAAGGGCGGCTGGTGCGGCTGGTGGAGAG
CCAGGAGCAGGTGGCGACTCTGCAACTGGTGGATACCCTCGAGGAGCAGGCGTTGCTCGAGGAGTTGCTGGAGTCCAGCA
AGCCGCCGCTGCCGGAAAGTGCCGAGCCGCTGCATTACCTGTTGAAGACGCCGTTCCGCTATCCGCCCTTGCGCTGGGGC
TCGCGCTTCGGTCGCCGGCATGAGCCAGGCCTGTTCTATGCCGCGCTGAAACTGGAGACAGCGATGGCCGAGGGCGCCTA
TTACCGTTGCGTCCTGTGGAGCGGCATGGCGGTGCCGCCGCCCAGTGGGCGGATCCTTTCCGAGCACGCCTCGTTCGAGG
CGGCCTGGAAGGTGGAGCGGGGCGTTCGCCTGCAGGAACCGCCTTTCTCCGACTACGAGCGCGCGCTGACCGATACCGCC
GACTACCGAGTCGCCCAGGAGCTGGGTAGTGCCATGCGCGGCGCCGGTGTACAGGCATTCGAGTATCGTTCGGCGCGTTG
CCCGCAGCGTGGCTGCAATGTCGCCCTGTTTACGCCGCGGGCCTTCATCGAGAAACGTCCGCGCAACCTGACCCCATGGC
TGTGCGAAACCACCGCCAGCTATGTGGCGTTCAAGCCTGCGCACGTGCCGGGCTCGCCGAAGGTGTTCGCTCGCGAACTG
TTCCTGGTGGACGGCCGCCTGCCCCAGCCGGCATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13353.60 Da Isoelectric Point: 9.9874
>AT75134 WP_003157715.1 NZ_CP020560:c4200408-4200040 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGILGVDRSAISRWKSQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDLRHFMRTPNHHLGGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGILGVDRSAISRWKSQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDLRHFMRTPNHHLGGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
>AT75134 NZ_CP020560:c4200408-4200040 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGCCCCAGTGCCGATGCCGTCCTGGCCAAGGCGGTGCTGGCCGCGCGCGAGCAGCTGGG
CCTGACGCAACTCGAACTGGCCGGGATCCTCGGCGTCGACCGCAGCGCCATCAGCCGCTGGAAGAGCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAACTGGCCCTGCTGCTCGTGCGGGTCTACCGCGCGCTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACCTGCGTCATTTCATGCGCACGCCCAACCATCACCTGGGCGGGGAGCCCCTGGCGCTGATGGGACAGGTACAGGG
CCTGGTGCATGTACTGGAGTACCTCGACGCGATCCGCGGCAAGGTCTGA
ATGAGCGCTCTCATCAAGGAACGCCCCAGTGCCGATGCCGTCCTGGCCAAGGCGGTGCTGGCCGCGCGCGAGCAGCTGGG
CCTGACGCAACTCGAACTGGCCGGGATCCTCGGCGTCGACCGCAGCGCCATCAGCCGCTGGAAGAGCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAACTGGCCCTGCTGCTCGTGCGGGTCTACCGCGCGCTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACCTGCGTCATTTCATGCGCACGCCCAACCATCACCTGGGCGGGGAGCCCCTGGCGCTGATGGGACAGGTACAGGG
CCTGGTGCATGTACTGGAGTACCTCGACGCGATCCGCGGCAAGGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A424XGP4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2R3IR82 |