Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3286302..3287523 Replicon chromosome
Accession NZ_CP020560
Organism Pseudomonas aeruginosa strain CR1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B7D75_RS15530 Protein ID WP_107114198.1
Coordinates 3286945..3287523 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B7D75_RS15525 Protein ID WP_034082653.1
Coordinates 3286302..3286856 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D75_RS15500 3281871..3282422 + 552 WP_107114196.1 XRE family transcriptional regulator -
B7D75_RS15505 3282419..3282817 - 399 WP_033997206.1 NADH-quinone oxidoreductase subunit A -
B7D75_RS15510 3282830..3283153 - 324 WP_012076113.1 quaternary ammonium compound efflux SMR transporter SugE -
B7D75_RS15515 3283483..3283944 + 462 WP_012076114.1 (2Fe-2S)-binding protein -
B7D75_RS15520 3283949..3286144 + 2196 WP_107114197.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
B7D75_RS15525 3286302..3286856 + 555 WP_034082653.1 helix-turn-helix domain-containing protein Antitoxin
B7D75_RS15530 3286945..3287523 + 579 WP_107114198.1 HD domain-containing protein Toxin
B7D75_RS15535 3287629..3288816 - 1188 WP_012076116.1 HlyD family efflux transporter periplasmic adaptor subunit -
B7D75_RS15540 3288806..3290977 - 2172 WP_043104503.1 type I secretion system permease/ATPase -
B7D75_RS15545 3290967..3292244 - 1278 WP_003153546.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-172)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21811.66 Da        Isoelectric Point: 5.3655

>T75133 WP_107114198.1 NZ_CP020560:3286945-3287523 [Pseudomonas aeruginosa]
MSLELLKNRLDFLSEAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKALRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T75133 NZ_CP020560:3286945-3287523 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAAGAACCGCCTCGACTTCCTCAGCGAAGCCGAACGCCTGAAAGATGTCCTGCGCTCCGCGCA
TACGTCTTCCGGTCGCCCGGAAAGCACCGCCGAACACAGTTGGCGGCTGTGCCTGATGGCGCTGGCCTTCGAGGATCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTACGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCG
GCCGTCGAGCAGGCCGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGTTGACTCGTCACCTCGACGC
GCCGCTGCGCGAACGCCTGCTCGCCCTGTGGGATGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGGCCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
GGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20379.48 Da        Isoelectric Point: 8.9546

>AT75133 WP_034082653.1 NZ_CP020560:3286302-3286856 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQAHAAELFGVAQSTISRWESGAQALRAEERTRLETLLGARLETAADRALARLVDGS
PQPMHLICDLTHRLLACSPARAAQFAVPLGDLLGRSLWPYCSEEILRQEAALDDLGWRELLAPPALEFASGTNASTIVPI
RRSRCRWTRLTLSDGRAVRLVETL

Download         Length: 555 bp

>AT75133 NZ_CP020560:3286302-3286856 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTTCCTTCTTCGTCCCTGGGCCCCGCCCTGCGCCGTTGGCGCCTGCTGCACCGGGTCAAGCAGGCGCA
CGCCGCCGAGCTGTTCGGCGTGGCCCAGTCGACCATCTCGCGCTGGGAATCCGGCGCCCAGGCGCTGCGAGCGGAGGAAC
GGACGCGCCTGGAAACCCTCCTCGGCGCCCGCCTGGAGACCGCCGCCGACCGGGCGCTGGCCCGCCTGGTCGATGGCAGC
CCGCAGCCGATGCATCTGATCTGCGACCTCACCCACCGCCTGCTGGCCTGCTCGCCGGCGCGCGCCGCGCAATTCGCCGT
CCCCCTCGGCGACCTGCTCGGCCGTTCGCTGTGGCCGTATTGCAGCGAGGAGATCCTCCGCCAGGAAGCCGCCCTCGACG
ACCTCGGCTGGCGCGAGCTGCTGGCGCCGCCGGCGCTGGAGTTCGCCAGCGGAACGAACGCCTCGACCATCGTGCCGATC
CGGCGCAGCCGCTGCCGCTGGACCCGCCTGACGCTCTCCGACGGCCGCGCGGTGCGGCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References