Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 146309..146814 | Replicon | chromosome |
Accession | NZ_CP020560 | ||
Organism | Pseudomonas aeruginosa strain CR1 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A3S0LZE8 |
Locus tag | B7D75_RS00675 | Protein ID | WP_003156094.1 |
Coordinates | 146309..146590 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A4P0TKN5 |
Locus tag | B7D75_RS00680 | Protein ID | WP_034081045.1 |
Coordinates | 146587..146814 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
B7D75_RS00650 | 141583..142932 | + | 1350 | WP_023443219.1 | C4-dicarboxylate transporter DctA | - |
B7D75_RS00655 | 142980..143666 | + | 687 | WP_011979163.1 | FadR family transcriptional regulator | - |
B7D75_RS00660 | 143767..144501 | + | 735 | WP_058145532.1 | GntR family transcriptional regulator | - |
B7D75_RS00665 | 144665..145066 | + | 402 | Protein_134 | aegerolysin family protein | - |
B7D75_RS00670 | 145133..146023 | - | 891 | WP_043099741.1 | LysR family transcriptional regulator | - |
B7D75_RS00675 | 146309..146590 | - | 282 | WP_003156094.1 | type II toxin-antitoxin system toxin ParE | Toxin |
B7D75_RS00680 | 146587..146814 | - | 228 | WP_034081045.1 | CopG family ribbon-helix-helix protein | Antitoxin |
B7D75_RS00685 | 146990..147610 | - | 621 | WP_107113641.1 | hypothetical protein | - |
B7D75_RS00690 | 147711..148211 | + | 501 | WP_034081042.1 | LEA type 2 family protein | - |
B7D75_RS00695 | 148284..148625 | + | 342 | WP_003101229.1 | alkylphosphonate utilization protein | - |
B7D75_RS00700 | 148745..150172 | - | 1428 | WP_107113642.1 | GABA permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10433.15 Da Isoelectric Point: 9.6558
>T75130 WP_003156094.1 NZ_CP020560:c146590-146309 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T75130 NZ_CP020560:c146590-146309 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACTCGCAAGGCGGCCGCCGACCTGGACGCCATCTATGACCACTACGTGGTGCTGATCGGCCCGGA
GAAAGCGCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTACAGGAGGTGGCCAACCAGGGCGCGGGGCGAC
CCAGCGAGGTGCCAGGCGTACGCACCCTGGCGCTGGAGCGCTGGCCGTTCAGCGCCCCATTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
ATGAGCCTGAAGTGGACTCGCAAGGCGGCCGCCGACCTGGACGCCATCTATGACCACTACGTGGTGCTGATCGGCCCGGA
GAAAGCGCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTACAGGAGGTGGCCAACCAGGGCGCGGGGCGAC
CCAGCGAGGTGCCAGGCGTACGCACCCTGGCGCTGGAGCGCTGGCCGTTCAGCGCCCCATTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8568.64 Da Isoelectric Point: 5.5740
>AT75130 WP_034081045.1 NZ_CP020560:c146814-146587 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHLEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHLEIEKRWGLQ
Download Length: 228 bp
>AT75130 NZ_CP020560:c146814-146587 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGATGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGGGA
CCGTCCGTACCACTTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCC
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACCTCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGATGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGGGA
CCGTCCGTACCACTTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCC
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACCTCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S0LZE8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4P0TKN5 |