Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 146309..146814 Replicon chromosome
Accession NZ_CP020560
Organism Pseudomonas aeruginosa strain CR1

Toxin (Protein)


Gene name parE Uniprot ID A0A3S0LZE8
Locus tag B7D75_RS00675 Protein ID WP_003156094.1
Coordinates 146309..146590 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4P0TKN5
Locus tag B7D75_RS00680 Protein ID WP_034081045.1
Coordinates 146587..146814 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D75_RS00650 141583..142932 + 1350 WP_023443219.1 C4-dicarboxylate transporter DctA -
B7D75_RS00655 142980..143666 + 687 WP_011979163.1 FadR family transcriptional regulator -
B7D75_RS00660 143767..144501 + 735 WP_058145532.1 GntR family transcriptional regulator -
B7D75_RS00665 144665..145066 + 402 Protein_134 aegerolysin family protein -
B7D75_RS00670 145133..146023 - 891 WP_043099741.1 LysR family transcriptional regulator -
B7D75_RS00675 146309..146590 - 282 WP_003156094.1 type II toxin-antitoxin system toxin ParE Toxin
B7D75_RS00680 146587..146814 - 228 WP_034081045.1 CopG family ribbon-helix-helix protein Antitoxin
B7D75_RS00685 146990..147610 - 621 WP_107113641.1 hypothetical protein -
B7D75_RS00690 147711..148211 + 501 WP_034081042.1 LEA type 2 family protein -
B7D75_RS00695 148284..148625 + 342 WP_003101229.1 alkylphosphonate utilization protein -
B7D75_RS00700 148745..150172 - 1428 WP_107113642.1 GABA permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10433.15 Da        Isoelectric Point: 9.6558

>T75130 WP_003156094.1 NZ_CP020560:c146590-146309 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T75130 NZ_CP020560:c146590-146309 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACTCGCAAGGCGGCCGCCGACCTGGACGCCATCTATGACCACTACGTGGTGCTGATCGGCCCGGA
GAAAGCGCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTACAGGAGGTGGCCAACCAGGGCGCGGGGCGAC
CCAGCGAGGTGCCAGGCGTACGCACCCTGGCGCTGGAGCGCTGGCCGTTCAGCGCCCCATTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT75130 WP_034081045.1 NZ_CP020560:c146814-146587 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHLEIEKRWGLQ

Download         Length: 228 bp

>AT75130 NZ_CP020560:c146814-146587 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGATGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGGGA
CCGTCCGTACCACTTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCC
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACCTCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0LZE8

Antitoxin

Source ID Structure
AlphaFold DB A0A4P0TKN5

References