Detailed information of TA system TA075112

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4902004..4902818
• Replicon: chromosome
• Accession: NZ_CP020545
• Organism: Escherichia coli strain ZJ3920

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: B6V57_RS25535
• Protein ID: WP_001054376.1
• Coordinates: 4902561..4902818 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: B6V57_RS25530
• Protein ID: WP_001309181.1
• Coordinates: 4902004..4902549 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6V57_RS25505	4897695..4899008	-	1314	WP_080282652.1	galactitol-specific PTS transporter subunit IIC	-
B6V57_RS25510	4899020..4899298	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
B6V57_RS25515	4899295..4900416	-	1122	WP_000010830.1	M42 family metallopeptidase	-
B6V57_RS28720	4900661..4900777	-	117	Protein_4654	VOC family protein	-
B6V57_RS25520	4900815..4901033	-	219	Protein_4655	hypothetical protein	-
B6V57_RS25525	4901202..4901948	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
B6V57_RS25530	4902004..4902549	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
B6V57_RS25535	4902561..4902818	-	258	WP_001054376.1	hypothetical protein	Toxin
B6V57_RS25545	4903195..4903440	-	246	Protein_4659	GNAT family N-acetyltransferase	-
B6V57_RS25555	4903556..4904796	+	1241	Protein_4660	helicase YjhR	-
B6V57_RS25560	4905379..4906359	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
B6V57_RS25565	4906424..4907371	-	948	Protein_4662	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T75112 WP_001054376.1 NZ_CP020545:c4902818-4902561 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T75112 NZ_CP020545:c4902818-4902561 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT75112 WP_001309181.1 NZ_CP020545:c4902549-4902004 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT75112 NZ_CP020545:c4902549-4902004 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8