Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4059579..4060174 Replicon chromosome
Accession NZ_CP020543
Organism Escherichia coli C

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag B6N50_RS20745 Protein ID WP_000239579.1
Coordinates 4059579..4059929 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A240D6C8
Locus tag B6N50_RS20750 Protein ID WP_001223212.1
Coordinates 4059923..4060174 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6N50_RS20725 (B6N50_20720) 4055025..4056047 - 1023 WP_001355798.1 ABC transporter permease -
B6N50_RS20730 (B6N50_20725) 4056061..4057563 - 1503 WP_000210553.1 sugar ABC transporter ATP-binding protein -
B6N50_RS20735 (B6N50_20730) 4057703..4058659 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
B6N50_RS20740 (B6N50_20735) 4058969..4059499 + 531 WP_000055072.1 inorganic diphosphatase -
B6N50_RS20745 (B6N50_20740) 4059579..4059929 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
B6N50_RS20750 (B6N50_20745) 4059923..4060174 - 252 WP_001223212.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
B6N50_RS20755 (B6N50_20750) 4060386..4060727 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
B6N50_RS20760 (B6N50_20755) 4060730..4064509 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T75078 WP_000239579.1 NZ_CP020543:c4059929-4059579 [Escherichia coli C]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T75078 NZ_CP020543:c4059929-4059579 [Escherichia coli C]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTTGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.6509

>AT75078 WP_001223212.1 NZ_CP020543:c4060174-4059923 [Escherichia coli C]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT75078 NZ_CP020543:c4060174-4059923 [Escherichia coli C]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A240D6C8

References