Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2582002..2582459 Replicon chromosome
Accession NZ_CP020538
Organism Sphingobium herbicidovorans strain MH

Toxin (Protein)


Gene name relE Uniprot ID A0A086PBL0
Locus tag B6S01_RS12845 Protein ID WP_037464182.1
Coordinates 2582002..2582277 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086PBL1
Locus tag B6S01_RS12850 Protein ID WP_037464184.1
Coordinates 2582277..2582459 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6S01_RS12810 2577407..2578156 + 750 WP_037464168.1 electron transfer flavoprotein subunit beta/FixA family protein -
B6S01_RS12815 2578239..2579168 + 930 WP_037464170.1 FAD-binding protein -
B6S01_RS12820 2579299..2579646 - 348 WP_037464172.1 glycine zipper 2TM domain-containing protein -
B6S01_RS12825 2579862..2580101 - 240 WP_037464259.1 hypothetical protein -
B6S01_RS12830 2580234..2580428 - 195 WP_037464175.1 hypothetical protein -
B6S01_RS12835 2580511..2580723 - 213 WP_037464177.1 cold-shock protein -
B6S01_RS12840 2580913..2581911 - 999 WP_037464180.1 hypothetical protein -
B6S01_RS12845 2582002..2582277 - 276 WP_037464182.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B6S01_RS12850 2582277..2582459 - 183 WP_037464184.1 hypothetical protein Antitoxin
B6S01_RS12855 2582656..2584095 + 1440 WP_037464187.1 hypothetical protein -
B6S01_RS12860 2584121..2587113 - 2993 Protein_2536 excinuclease ABC subunit UvrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10607.23 Da        Isoelectric Point: 9.3119

>T75051 WP_037464182.1 NZ_CP020538:c2582277-2582002 [Sphingobium herbicidovorans]
MPHVIWRPIAREDARRIIDYISDRNPAAAARLAELLEYTATRLADHPYMYRAGRVPETREALVTPNYMLVYRVGADVIEI
LTVKHTRQQYP

Download         Length: 276 bp

>T75051 NZ_CP020538:c2582277-2582002 [Sphingobium herbicidovorans]
ATGCCGCACGTTATTTGGCGCCCGATCGCGCGCGAGGATGCGCGGCGCATCATCGACTATATCTCTGATCGCAATCCCGC
CGCTGCCGCTCGCCTTGCAGAACTGCTGGAATATACCGCCACTCGCTTGGCCGATCATCCCTACATGTATCGCGCCGGTC
GTGTCCCCGAGACGCGGGAAGCCCTCGTCACCCCCAATTACATGCTCGTCTACCGCGTCGGAGCCGACGTCATAGAAATA
TTGACCGTCAAACACACCCGGCAACAATATCCCTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6709.61 Da        Isoelectric Point: 4.7144

>AT75051 WP_037464184.1 NZ_CP020538:c2582459-2582277 [Sphingobium herbicidovorans]
MTKLTPIESEFATTEEAEAYDAWFRAQVEASLADPRPGIPHDQVMAELRAIIEAKKAKHV

Download         Length: 183 bp

>AT75051 NZ_CP020538:c2582459-2582277 [Sphingobium herbicidovorans]
ATGACCAAACTCACCCCCATCGAGTCCGAGTTCGCGACGACCGAGGAAGCCGAGGCTTATGACGCCTGGTTTCGCGCACA
GGTGGAGGCGTCCTTGGCCGATCCCCGGCCCGGCATCCCGCACGATCAGGTCATGGCGGAACTGCGCGCGATCATTGAGG
CGAAGAAAGCCAAGCACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086PBL0

Antitoxin

Source ID Structure
AlphaFold DB A0A086PBL1

References