Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1135433..1135961 Replicon chromosome
Accession NZ_CP020533
Organism Vibrio anguillarum strain 425

Toxin (Protein)


Gene name relE Uniprot ID F7YRA6
Locus tag B5S57_RS05500 Protein ID WP_013868556.1
Coordinates 1135674..1135961 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F7YRA5
Locus tag B5S57_RS05495 Protein ID WP_013868555.1
Coordinates 1135433..1135684 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5S57_RS20430 1130669..1130944 + 276 WP_013868550.1 hypothetical protein -
B5S57_RS05460 1131303..1132844 - 1542 WP_011154650.1 IS66-like element ISVa5 family transposase -
B5S57_RS05465 1132904..1133257 - 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -
B5S57_RS05470 1133254..1133571 - 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
B5S57_RS05475 1133654..1134487 - 834 Protein_1001 IS30-like element ISVa6 family transposase -
B5S57_RS05485 1134734..1135219 + 486 WP_107489895.1 hypothetical protein -
B5S57_RS05495 1135433..1135684 + 252 WP_013868555.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B5S57_RS05500 1135674..1135961 + 288 WP_013868556.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5S57_RS05515 1137034..1137312 - 279 WP_010320663.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
B5S57_RS05520 1137309..1137593 - 285 WP_017040620.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
B5S57_RS05530 1138793..1139152 + 360 WP_019281417.1 VOC family protein -
B5S57_RS05540 1139843..1140283 + 441 WP_040122767.1 hypothetical protein -
B5S57_RS05545 1140440..1140907 + 468 WP_001289286.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1129204..1141490 12286


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-70)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11064.07 Da        Isoelectric Point: 10.5506

>T75049 WP_013868556.1 NZ_CP020533:1135674-1135961 [Vibrio anguillarum]
MTYKLKFLPAAKKEWSKLAPPIQSQFKKKLKERLENPHVPSSKLRGYDSVYKIKLRTAGYRLAYEVIDDEIVVYVLAIGK
RDKDAVYKKLASRFS

Download         Length: 288 bp

>T75049 NZ_CP020533:1135674-1135961 [Vibrio anguillarum]
ATGACTTATAAGCTAAAATTTCTACCGGCTGCCAAGAAAGAGTGGAGTAAGTTAGCTCCACCAATTCAAAGTCAGTTCAA
AAAGAAGCTTAAAGAGCGTCTGGAAAACCCGCATGTTCCTTCTTCTAAACTGCGTGGCTATGACTCAGTTTATAAGATCA
AACTACGTACAGCAGGCTATCGCTTAGCCTATGAAGTCATTGATGATGAAATCGTGGTGTACGTGTTAGCTATTGGAAAA
CGAGATAAAGATGCAGTGTACAAAAAGTTAGCATCAAGGTTCTCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9154.36 Da        Isoelectric Point: 4.0414

>AT75049 WP_013868555.1 NZ_CP020533:1135433-1135684 [Vibrio anguillarum]
MRQVLADCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEFLMDMLDDYELAKLVESRRGELSEAVEVNI
DDL

Download         Length: 252 bp

>AT75049 NZ_CP020533:1135433-1135684 [Vibrio anguillarum]
ATGAGACAGGTTTTAGCTGATTGTTCTGCAAGTATTTCTGAGTTAAAGAAAAATCCAACCGCTTTACTAAACGAAGCTGA
TGGTTCTGCCATTGCTATTCTAAACCACAATAAGCCAGCAGCTTATCTTGTCCCAGCAGAAACTTATGAGTTTCTAATGG
ATATGCTCGATGACTATGAGCTTGCTAAACTAGTTGAAAGTCGCCGTGGTGAATTGTCTGAAGCGGTGGAAGTAAATATC
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E5BHG0

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8TZB8

References