Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 178468..179234 Replicon chromosome
Accession NZ_CP020533
Organism Vibrio anguillarum strain 425

Toxin (Protein)


Gene name - Uniprot ID F7YRS3
Locus tag B5S57_RS01340 Protein ID WP_013867769.1
Coordinates 178468..178965 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F7YRS4
Locus tag B5S57_RS01345 Protein ID WP_013867770.1
Coordinates 178962..179234 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5S57_RS01295 174937..175290 - 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -
B5S57_RS01300 175287..175604 - 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
B5S57_RS01305 175719..175811 + 93 WP_019281220.1 DUF3265 domain-containing protein -
B5S57_RS01310 175899..176105 + 207 WP_013867765.1 DUF1289 domain-containing protein -
B5S57_RS01315 176225..176455 - 231 WP_013867766.1 PAS factor family protein -
B5S57_RS01320 176749..176985 - 237 WP_013867767.1 hypothetical protein -
B5S57_RS01325 177270..177758 + 489 WP_013867768.1 hypothetical protein -
B5S57_RS01330 177749..177880 + 132 Protein_177 DUF3265 domain-containing protein -
B5S57_RS01340 178468..178965 - 498 WP_013867769.1 GNAT family N-acetyltransferase Toxin
B5S57_RS01345 178962..179234 - 273 WP_013867770.1 DUF1778 domain-containing protein Antitoxin
B5S57_RS01355 179985..180704 + 720 Protein_180 hypothetical protein -
B5S57_RS01360 180761..181681 - 921 WP_011154643.1 IS5-like element ISVa2 family transposase -
B5S57_RS01365 181786..182073 + 288 WP_157727321.1 potassium channel family protein -
B5S57_RS01370 182099..183067 - 969 WP_076611895.1 IS30-like element ISVa6 family transposase -
B5S57_RS01380 183440..183829 + 390 WP_019280976.1 DUF1090 domain-containing protein -
B5S57_RS01385 183833..183922 + 90 WP_019280977.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 138852..183829 44977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18525.25 Da        Isoelectric Point: 9.2555

>T75048 WP_013867769.1 NZ_CP020533:c178965-178468 [Vibrio anguillarum]
MMNTVLLDKVKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSSHIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKYFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T75048 NZ_CP020533:c178965-178468 [Vibrio anguillarum]
ATGATGAATACGGTACTTTTAGATAAAGTTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAAGACAACACCAGAACGTTTGTTCTGGAAGATGATAACAACAGCTCAC
ATATCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAATTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGCCTAATTGCCCGTCTTGCTGTCGATGACAGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
CATCGATGCACTCAGAAAGCTATTAGCTGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CAAAATATTTTTATGAACGCTATGGCTTTCAGGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCGGATGTA
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9731.18 Da        Isoelectric Point: 8.6154

>AT75048 WP_013867770.1 NZ_CP020533:c179234-178962 [Vibrio anguillarum]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAILLMDALDRPTAQNSKLRA
ASERYESKAQ

Download         Length: 273 bp

>AT75048 NZ_CP020533:c179234-178962 [Vibrio anguillarum]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGATTTACTCACTAAAGCTGCCGCTATCGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGCGCTGCAATTGAAAAGGCTAAACAAGTCATCGAACGTGAGCAAGCTT
TAAAACTGAGCCAAGCCGATGCGATTTTGCTGATGGACGCATTAGACCGCCCAACAGCACAGAACTCAAAACTAAGAGCG
GCCTCTGAACGATACGAGAGCAAGGCTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3QZT4

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8U164

References