Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3925651..3926308 Replicon chromosome
Accession NZ_CP020528
Organism Enterobacter cloacae strain 174

Toxin (Protein)


Gene name cptA Uniprot ID A0A837FG63
Locus tag AXJ76_RS19600 Protein ID WP_003863439.1
Coordinates 3925651..3926061 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AXJ76_RS19605 Protein ID WP_003863437.1
Coordinates 3926042..3926308 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXJ76_RS19580 3921649..3923382 - 1734 WP_045350796.1 single-stranded-DNA-specific exonuclease RecJ -
AXJ76_RS19585 3923388..3924101 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AXJ76_RS19590 3924130..3925026 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AXJ76_RS19595 3925128..3925649 + 522 WP_003863440.1 flavodoxin FldB -
AXJ76_RS19600 3925651..3926061 - 411 WP_003863439.1 protein YgfX Toxin
AXJ76_RS19605 3926042..3926308 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AXJ76_RS19610 3926603..3927583 + 981 WP_003863435.1 tRNA-modifying protein YgfZ -
AXJ76_RS19615 3927669..3928328 - 660 WP_003863433.1 hemolysin III family protein -
AXJ76_RS19620 3928595..3929326 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
AXJ76_RS19625 3929443..3930876 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16339.24 Da        Isoelectric Point: 11.4775

>T75043 WP_003863439.1 NZ_CP020528:c3926061-3925651 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T75043 NZ_CP020528:c3926061-3925651 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCGA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT75043 WP_003863437.1 NZ_CP020528:c3926308-3926042 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT75043 NZ_CP020528:c3926308-3926042 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FG63

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References