Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3002873..3003717 Replicon chromosome
Accession NZ_CP020514
Organism Escherichia coli strain 219

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag A9P12_RS15585 Protein ID WP_000854686.1
Coordinates 3002873..3003256 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag A9P12_RS15590 Protein ID WP_001285602.1
Coordinates 3003337..3003717 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P12_RS15545 2997876..2998367 - 492 WP_001300785.1 DUF1097 domain-containing protein -
A9P12_RS15550 2998469..2999023 - 555 WP_001001921.1 molecular chaperone YcdY -
A9P12_RS15555 2999047..2999784 - 738 WP_000283667.1 zinc-binding phosphatase -
A9P12_RS15560 2999839..3000777 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
A9P12_RS15570 3001248..3002089 - 842 Protein_2855 DUF4942 domain-containing protein -
A9P12_RS15575 3002174..3002371 - 198 WP_000839253.1 DUF957 domain-containing protein -
A9P12_RS15580 3002388..3002876 - 489 WP_032180032.1 hypothetical protein -
A9P12_RS15585 3002873..3003256 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
A9P12_RS15590 3003337..3003717 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A9P12_RS15595 3003728..3004411 - 684 WP_000086768.1 hypothetical protein -
A9P12_RS15600 3004430..3004651 - 222 WP_000692298.1 DUF987 domain-containing protein -
A9P12_RS15605 3004714..3005190 - 477 WP_001186726.1 RadC family protein -
A9P12_RS15610 3005206..3005691 - 486 WP_000214307.1 antirestriction protein -
A9P12_RS15615 3005783..3006604 - 822 WP_001761104.1 DUF945 domain-containing protein -
A9P12_RS15625 3006705..3006913 - 209 Protein_2865 DUF905 domain-containing protein -
A9P12_RS15630 3007014..3007469 - 456 WP_000581506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCMY-2 csgB / csgD / csgE / csgF / csgG 2994257..3050203 55946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T74918 WP_000854686.1 NZ_CP020514:c3003256-3002873 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T74918 NZ_CP020514:c3003256-3002873 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT74918 WP_001285602.1 NZ_CP020514:c3003717-3003337 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT74918 NZ_CP020514:c3003717-3003337 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References