Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 51981..52779 Replicon chromosome
Accession NZ_CP020514
Organism Escherichia coli strain 219

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag A9P12_RS00300 Protein ID WP_000854735.1
Coordinates 51981..52358 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag A9P12_RS00305 Protein ID WP_001285415.1
Coordinates 52405..52779 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P12_RS00275 48895..49026 - 132 Protein_47 DUF4942 domain-containing protein -
A9P12_RS00280 49087..50220 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
A9P12_RS00285 50477..51184 - 708 Protein_49 DUF4942 domain-containing protein -
A9P12_RS00290 51281..51478 - 198 WP_000839266.1 DUF957 domain-containing protein -
A9P12_RS00295 51496..51984 - 489 WP_000761680.1 hypothetical protein -
A9P12_RS00300 51981..52358 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
A9P12_RS00305 52405..52779 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A9P12_RS00310 52859..53080 - 222 WP_000692309.1 DUF987 domain-containing protein -
A9P12_RS00315 53143..53619 - 477 WP_001342696.1 RadC family protein -
A9P12_RS00325 53634..54113 - 480 WP_001757700.1 antirestriction protein -
A9P12_RS00330 54195..55013 - 819 WP_113344608.1 DUF945 domain-containing protein -
A9P12_RS00335 55103..55336 - 234 WP_001278287.1 DUF905 family protein -
A9P12_RS00340 55342..56019 - 678 WP_001097301.1 hypothetical protein -
A9P12_RS00345 56167..56847 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 49087..50220 1133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T74899 WP_000854735.1 NZ_CP020514:c52358-51981 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T74899 NZ_CP020514:c52358-51981 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT74899 WP_001285415.1 NZ_CP020514:c52779-52405 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT74899 NZ_CP020514:c52779-52405 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References