Detailed information of TA system TA074859

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4264688..4265357
• Replicon: chromosome
• Accession: NZ_CP020507
• Organism: Serratia marcescens strain BWH-35

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AS658_RS20625
• Protein ID: WP_048234633.1
• Coordinates: 4264688..4265110 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: AS658_RS20630
• Protein ID: WP_019455657.1
• Coordinates: 4265091..4265357 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AS658_RS20605	4260621..4262354	-	1734	WP_038871239.1	single-stranded-DNA-specific exonuclease RecJ	-
AS658_RS20610	4262361..4263077	-	717	WP_038871236.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AS658_RS20615	4263104..4264003	-	900	WP_038871248.1	site-specific tyrosine recombinase XerD	-
AS658_RS20620	4264110..4264628	+	519	WP_038871234.1	flavodoxin FldB	-
AS658_RS20625	4264688..4265110	-	423	WP_048234633.1	protein YgfX	Toxin
AS658_RS20630	4265091..4265357	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
AS658_RS20635	4265678..4266670	+	993	WP_038871228.1	tRNA-modifying protein YgfZ	-
AS658_RS20640	4266709..4267206	-	498	WP_038871226.1	DUF2165 domain-containing protein	-
AS658_RS20645	4267357..4268031	-	675	WP_038871224.1	hemolysin III family protein	-
AS658_RS20650	4268215..4268823	+	609	WP_048234634.1	HD domain-containing protein	-
AS658_RS20655	4268856..4269782	-	927	WP_048234635.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16528.58 Da
• Isoelectric Point: 10.8114

>T74859 WP_048234633.1 NZ_CP020507:c4265110-4264688 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPTGDGEPE

Nucleotide

• Length: 423 bp

>T74859 NZ_CP020507:c4265110-4264688 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGTTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCTCCGA
CGGGTGACGGCGAACCAGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT74859 WP_019455657.1 NZ_CP020507:c4265357-4265091 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT74859 NZ_CP020507:c4265357-4265091 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04