74857

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3939263..3939919 Replicon chromosome
Accession NZ_CP020507
Organism Serratia marcescens strain BWH-35

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AS658_RS19050 Protein ID WP_038873757.1
Coordinates 3939263..3939652 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag AS658_RS19055 Protein ID WP_004941563.1
Coordinates 3939656..3939919 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS658_RS19035 3935732..3937162 + 1431 WP_038873750.1 multidrug transporter subunit MdtD -
AS658_RS19040 3937159..3938532 + 1374 WP_038873752.1 two-component system sensor histidine kinase BaeS -
AS658_RS19045 3938542..3939258 + 717 WP_038873754.1 two-component system response regulator BaeR -
AS658_RS19050 3939263..3939652 - 390 WP_038873757.1 type II toxin-antitoxin system VapC family toxin Toxin
AS658_RS19055 3939656..3939919 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AS658_RS19060 3940258..3940596 + 339 WP_038873760.1 YegP family protein -
AS658_RS19065 3940898..3942250 + 1353 WP_038873761.1 tRNA 5-hydroxyuridine modification protein YegQ -
AS658_RS19070 3942481..3943512 + 1032 WP_001395480.1 IS630-like element ISEc33 family transposase -
AS658_RS19075 3943873..3944778 + 906 WP_048234537.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3942961..3943512 551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14318.53 Da        Isoelectric Point: 7.3214

>T74857 WP_038873757.1 NZ_CP020507:c3939652-3939263 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSHGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T74857 NZ_CP020507:c3939652-3939263 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAAGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAGAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCATGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT74857 WP_004941563.1 NZ_CP020507:c3939919-3939656 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT74857 NZ_CP020507:c3939919-3939656 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References