74856

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3857935..3858497 Replicon chromosome
Accession NZ_CP020507
Organism Serratia marcescens strain BWH-35

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag AS658_RS18675 Protein ID WP_047730131.1
Coordinates 3857935..3858291 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag AS658_RS18680 Protein ID WP_004936539.1
Coordinates 3858288..3858497 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS658_RS18655 3853669..3854466 - 798 WP_038881261.1 energy transducer TonB -
AS658_RS18660 3854569..3855408 - 840 WP_038881258.1 ChaN family lipoprotein -
AS658_RS18665 3855586..3856995 + 1410 WP_038881254.1 S-methylmethionine permease -
AS658_RS18670 3856985..3857923 + 939 WP_047730132.1 homocysteine S-methyltransferase -
AS658_RS18675 3857935..3858291 - 357 WP_047730131.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AS658_RS18680 3858288..3858497 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AS658_RS18685 3858607..3860886 - 2280 WP_038881248.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
AS658_RS27060 3861102..3861275 - 174 WP_038881246.1 hypothetical protein -
AS658_RS18690 3861256..3861636 - 381 WP_048234508.1 DUF2570 family protein -
AS658_RS18695 3861633..3862034 - 402 WP_038881240.1 M15 family metallopeptidase -
AS658_RS18700 3862024..3862350 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13161.95 Da        Isoelectric Point: 4.9139

>T74856 WP_047730131.1 NZ_CP020507:c3858291-3857935 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE

Download         Length: 357 bp

>T74856 NZ_CP020507:c3858291-3857935 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATAGTGCCTCACGGCCGCCAGGAAGGCAGAAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCTGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT74856 WP_004936539.1 NZ_CP020507:c3858497-3858288 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT74856 NZ_CP020507:c3858497-3858288 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTCTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References