Detailed information of TA system TA074855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3191275..3191906
• Replicon: chromosome
• Accession: NZ_CP020507
• Organism: Serratia marcescens strain BWH-35

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AS658_RS15620
• Protein ID: WP_048234362.1
• Coordinates: 3191275..3191673 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0G3SVC2
• Locus tag: AS658_RS15625
• Protein ID: WP_047730457.1
• Coordinates: 3191673..3191906 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AS658_RS15600	3186378..3187193	-	816	WP_047730461.1	5'-nucleotidase, lipoprotein e(P4) family	-
AS658_RS15605	3187522..3187926	-	405	WP_047730460.1	flagellar protein FlhE	-
AS658_RS15610	3187926..3190004	-	2079	WP_038876828.1	flagellar biosynthesis protein FlhA	-
AS658_RS15615	3189997..3191148	-	1152	WP_047730459.1	flagellar type III secretion system protein FlhB	-
AS658_RS15620	3191275..3191673	-	399	WP_048234362.1	tRNA(fMet)-specific endonuclease VapC	Toxin
AS658_RS15625	3191673..3191906	-	234	WP_047730457.1	antitoxin	Antitoxin
AS658_RS15630	3192032..3192676	-	645	WP_004934858.1	protein phosphatase CheZ	-
AS658_RS15635	3192687..3193076	-	390	WP_004934862.1	chemotaxis response regulator CheY	-
AS658_RS15640	3193179..3194228	-	1050	WP_015378262.1	chemotaxis response regulator protein-glutamate methylesterase	-
AS658_RS15645	3194228..3195100	-	873	WP_025159837.1	protein-glutamate O-methyltransferase CheR	-
AS658_RS15650	3195138..3196754	-	1617	WP_048234363.1	Tar ligand binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14907.09 Da
• Isoelectric Point: 6.9789

>T74855 WP_048234362.1 NZ_CP020507:c3191673-3191275 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEVFNRYAGKMVISSITYGELVHGVENSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAVLERQGTPIGVNDLHIAGHARSEGLILVTNNRREFECVEGLRLENWL

Nucleotide

• Length: 399 bp

>T74855 NZ_CP020507:c3191673-3191275 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGTATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGTGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8841.85 Da
• Isoelectric Point: 4.7815

>AT74855 WP_047730457.1 NZ_CP020507:c3191906-3191673 [Serratia marcescens]
MALGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Nucleotide

• Length: 234 bp

>AT74855 NZ_CP020507:c3191906-3191673 [Serratia marcescens]
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0G3SVC2