74846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1071008..1071630 Replicon chromosome
Accession NZ_CP020507
Organism Serratia marcescens strain BWH-35

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag AS658_RS05165 Protein ID WP_004940313.1
Coordinates 1071008..1071211 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag AS658_RS05170 Protein ID WP_004940312.1
Coordinates 1071262..1071630 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS658_RS05145 1067497..1068168 + 672 WP_038876207.1 hypothetical protein -
AS658_RS05150 1068165..1069277 + 1113 WP_017145378.1 ImmA/IrrE family metallo-endopeptidase -
AS658_RS05155 1069448..1070615 - 1168 Protein_969 IS3 family transposase -
AS658_RS05165 1071008..1071211 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
AS658_RS05170 1071262..1071630 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
AS658_RS05175 1071789..1072142 - 354 WP_048232846.1 hypothetical protein -
AS658_RS05180 1072552..1073265 + 714 WP_038874977.1 ABC transporter ATP-binding protein -
AS658_RS05185 1073262..1074119 + 858 WP_038874980.1 metal ABC transporter permease -
AS658_RS05190 1074145..1075023 + 879 WP_038874983.1 zinc ABC transporter substrate-binding protein -
AS658_RS05195 1075086..1076291 - 1206 WP_075335767.1 ISL3 family transposase -
AS658_RS05200 1076448..1076588 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1063469..1072142 8673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T74846 WP_004940313.1 NZ_CP020507:c1071211-1071008 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T74846 NZ_CP020507:c1071211-1071008 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT74846 WP_004940312.1 NZ_CP020507:c1071630-1071262 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT74846 NZ_CP020507:c1071630-1071262 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
GACCTTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References