Detailed information of TA system TA074845

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 896937..897595
• Replicon: chromosome
• Accession: NZ_CP020507
• Organism: Serratia marcescens strain BWH-35

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: AS658_RS04275
• Protein ID: WP_032637385.1
• Coordinates: 896937..897257 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: AS658_RS04280
• Protein ID: WP_032637384.1
• Coordinates: 897278..897595 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AS658_RS04255	891988..893526	+	1539	WP_032637388.1	sugar ABC transporter ATP-binding protein	-
AS658_RS04260	893529..894611	+	1083	WP_006809988.1	ABC transporter permease	-
AS658_RS04265	894700..895650	+	951	WP_048232733.1	D-ribose ABC transporter substrate-binding protein	-
AS658_RS04270	895781..896638	+	858	WP_048232736.1	DeoR/GlpR family DNA-binding transcription regulator	-
AS658_RS04275	896937..897257	-	321	WP_032637385.1	TA system toxin CbtA family protein	Toxin
AS658_RS04280	897278..897595	-	318	WP_032637384.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AS658_RS04285	897614..897835	-	222	WP_032637383.1	DUF987 domain-containing protein	-
AS658_RS04290	897844..898320	-	477	WP_000811693.1	RadC family protein	-
AS658_RS04295	898336..898815	-	480	WP_015063037.1	antirestriction protein	-
AS658_RS04305	899677..901872	-	2196	WP_048232739.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-104)

Antitoxin

• Antitoxin CbeA (5-103)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12146.14 Da
• Isoelectric Point: 7.1656

>T74845 WP_032637385.1 NZ_CP020507:c897257-896937 [Serratia marcescens]
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPFITAVDILKARRAMREMRT

Nucleotide

• Length: 321 bp

>T74845 NZ_CP020507:c897257-896937 [Serratia marcescens]
ATGAAAACTCTACCCGCAACGACTTTGTGGGCGGCTAAACCATGCCCGTCACCAGTGATCGTATGGCAAATGCTTCTTTC
ACGTCTGCTGGATCAGCACTATGGCCTGACACTGAATGACACGCCATTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCTCTTTAGCCGATGCCGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGCATCGATCGTAAGGGGTTT
AGCTGGCAAGAACAGTCGCCTTTTATTACTGCTGTAGACATTCTAAAAGCCAGACGGGCTATGAGGGAAATGAGAACATA
A

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12020.58 Da
• Isoelectric Point: 6.7389

>AT74845 WP_032637384.1 NZ_CP020507:c897595-897278 [Serratia marcescens]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHAHCVTLYH
NGFTCEADTLGSCGYVYITVYPTHR

Nucleotide

• Length: 318 bp

>AT74845 NZ_CP020507:c897595-897278 [Serratia marcescens]
ATGAGCAACATTACATGGGGGCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGTAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGCCATGCCCACTGCGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCACCGTTTATCCCACTCACCGATAA