Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 13703..14229 Replicon plasmid unnamed1
Accession NZ_CP020506
Organism Serratia marcescens strain 95

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag AM681_RS26280 Protein ID WP_000323025.1
Coordinates 13703..13990 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag AM681_RS26285 Protein ID WP_000534857.1
Coordinates 13990..14229 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM681_RS26240 8780..9391 + 612 WP_022652283.1 DUF2913 family protein -
AM681_RS26245 9388..10338 - 951 WP_022652284.1 Rpn family recombination-promoting nuclease/putative transposase -
AM681_RS26250 10485..10685 - 201 WP_040219232.1 hypothetical protein -
AM681_RS26255 10739..11371 - 633 WP_022652286.1 recombinase family protein -
AM681_RS26260 11550..11744 - 195 Protein_13 endonuclease -
AM681_RS26265 11885..12901 - 1017 WP_086528432.1 IS5-like element IS5 family transposase -
AM681_RS26275 13196..13420 - 225 Protein_15 hypothetical protein -
AM681_RS26280 13703..13990 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
AM681_RS26285 13990..14229 - 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
AM681_RS26290 14486..15226 + 741 WP_022652289.1 hypothetical protein -
AM681_RS26295 15436..16596 + 1161 WP_075335826.1 IS30 family transposase -
AM681_RS26300 16991..17596 - 606 WP_000509966.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..219979 219979
- inside IScluster/Tn - - 1074..21300 20226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T74837 WP_000323025.1 NZ_CP020506:c13990-13703 [Serratia marcescens]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T74837 NZ_CP020506:c13990-13703 [Serratia marcescens]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9085.55 Da        Isoelectric Point: 4.6820

>AT74837 WP_000534857.1 NZ_CP020506:c14229-13990 [Serratia marcescens]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL

Download         Length: 240 bp

>AT74837 NZ_CP020506:c14229-13990 [Serratia marcescens]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAAGCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References