Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 13703..14229 | Replicon | plasmid unnamed1 |
Accession | NZ_CP020506 | ||
Organism | Serratia marcescens strain 95 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | AM681_RS26280 | Protein ID | WP_000323025.1 |
Coordinates | 13703..13990 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q5J3S4 |
Locus tag | AM681_RS26285 | Protein ID | WP_000534857.1 |
Coordinates | 13990..14229 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM681_RS26240 | 8780..9391 | + | 612 | WP_022652283.1 | DUF2913 family protein | - |
AM681_RS26245 | 9388..10338 | - | 951 | WP_022652284.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
AM681_RS26250 | 10485..10685 | - | 201 | WP_040219232.1 | hypothetical protein | - |
AM681_RS26255 | 10739..11371 | - | 633 | WP_022652286.1 | recombinase family protein | - |
AM681_RS26260 | 11550..11744 | - | 195 | Protein_13 | endonuclease | - |
AM681_RS26265 | 11885..12901 | - | 1017 | WP_086528432.1 | IS5-like element IS5 family transposase | - |
AM681_RS26275 | 13196..13420 | - | 225 | Protein_15 | hypothetical protein | - |
AM681_RS26280 | 13703..13990 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
AM681_RS26285 | 13990..14229 | - | 240 | WP_000534857.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
AM681_RS26290 | 14486..15226 | + | 741 | WP_022652289.1 | hypothetical protein | - |
AM681_RS26295 | 15436..16596 | + | 1161 | WP_075335826.1 | IS30 family transposase | - |
AM681_RS26300 | 16991..17596 | - | 606 | WP_000509966.1 | recombinase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | - | 1..219979 | 219979 | |
- | inside | IScluster/Tn | - | - | 1074..21300 | 20226 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T74837 WP_000323025.1 NZ_CP020506:c13990-13703 [Serratia marcescens]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T74837 NZ_CP020506:c13990-13703 [Serratia marcescens]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9085.55 Da Isoelectric Point: 4.6820
>AT74837 WP_000534857.1 NZ_CP020506:c14229-13990 [Serratia marcescens]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL
Download Length: 240 bp
>AT74837 NZ_CP020506:c14229-13990 [Serratia marcescens]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAAGCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAAGCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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