Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3942456..3943112 Replicon chromosome
Accession NZ_CP020503
Organism Serratia marcescens strain 95

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AM681_RS19070 Protein ID WP_038873757.1
Coordinates 3942456..3942845 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag AM681_RS19075 Protein ID WP_004941563.1
Coordinates 3942849..3943112 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM681_RS19055 3938925..3940355 + 1431 WP_038873750.1 multidrug transporter subunit MdtD -
AM681_RS19060 3940352..3941725 + 1374 WP_038873752.1 two-component system sensor histidine kinase BaeS -
AM681_RS19065 3941735..3942451 + 717 WP_038873754.1 two-component system response regulator BaeR -
AM681_RS19070 3942456..3942845 - 390 WP_038873757.1 type II toxin-antitoxin system VapC family toxin Toxin
AM681_RS19075 3942849..3943112 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AM681_RS19080 3943451..3943789 + 339 WP_038873760.1 YegP family protein -
AM681_RS19085 3944091..3945443 + 1353 WP_038873761.1 tRNA 5-hydroxyuridine modification protein YegQ -
AM681_RS19090 3945674..3946705 + 1032 WP_001395480.1 IS630-like element ISEc33 family transposase -
AM681_RS19095 3947066..3947971 + 906 WP_048234537.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3946154..3946705 551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14318.53 Da        Isoelectric Point: 7.3214

>T74834 WP_038873757.1 NZ_CP020503:c3942845-3942456 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSHGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T74834 NZ_CP020503:c3942845-3942456 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAAGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAGAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCATGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT74834 WP_004941563.1 NZ_CP020503:c3943112-3942849 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT74834 NZ_CP020503:c3943112-3942849 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References