Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3859929..3860491 Replicon chromosome
Accession NZ_CP020503
Organism Serratia marcescens strain 95

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag AM681_RS18690 Protein ID WP_047730131.1
Coordinates 3859929..3860285 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag AM681_RS18695 Protein ID WP_004936539.1
Coordinates 3860282..3860491 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM681_RS18670 3855663..3856460 - 798 WP_038881261.1 energy transducer TonB -
AM681_RS18675 3856563..3857402 - 840 WP_038881258.1 ChaN family lipoprotein -
AM681_RS18680 3857580..3858989 + 1410 WP_038881254.1 S-methylmethionine permease -
AM681_RS18685 3858979..3859917 + 939 WP_047730132.1 homocysteine S-methyltransferase -
AM681_RS18690 3859929..3860285 - 357 WP_047730131.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AM681_RS18695 3860282..3860491 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AM681_RS18700 3860601..3862880 - 2280 WP_038881248.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
AM681_RS27815 3863096..3863269 - 174 WP_038881246.1 hypothetical protein -
AM681_RS18705 3863250..3863630 - 381 WP_048234508.1 DUF2570 family protein -
AM681_RS18710 3863627..3864028 - 402 WP_038881240.1 M15 family metallopeptidase -
AM681_RS18715 3864018..3864344 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13161.95 Da        Isoelectric Point: 4.9139

>T74833 WP_047730131.1 NZ_CP020503:c3860285-3859929 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE

Download         Length: 357 bp

>T74833 NZ_CP020503:c3860285-3859929 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATAGTGCCTCACGGCCGCCAGGAAGGCAGAAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCTGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT74833 WP_004936539.1 NZ_CP020503:c3860491-3860282 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT74833 NZ_CP020503:c3860491-3860282 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTCTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References