Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 3859929..3860491 | Replicon | chromosome |
Accession | NZ_CP020503 | ||
Organism | Serratia marcescens strain 95 |
Toxin (Protein)
Gene name | doc | Uniprot ID | - |
Locus tag | AM681_RS18690 | Protein ID | WP_047730131.1 |
Coordinates | 3859929..3860285 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | A0A8G2G5I1 |
Locus tag | AM681_RS18695 | Protein ID | WP_004936539.1 |
Coordinates | 3860282..3860491 (-) | Length | 70 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM681_RS18670 | 3855663..3856460 | - | 798 | WP_038881261.1 | energy transducer TonB | - |
AM681_RS18675 | 3856563..3857402 | - | 840 | WP_038881258.1 | ChaN family lipoprotein | - |
AM681_RS18680 | 3857580..3858989 | + | 1410 | WP_038881254.1 | S-methylmethionine permease | - |
AM681_RS18685 | 3858979..3859917 | + | 939 | WP_047730132.1 | homocysteine S-methyltransferase | - |
AM681_RS18690 | 3859929..3860285 | - | 357 | WP_047730131.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
AM681_RS18695 | 3860282..3860491 | - | 210 | WP_004936539.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
AM681_RS18700 | 3860601..3862880 | - | 2280 | WP_038881248.1 | NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase | - |
AM681_RS27815 | 3863096..3863269 | - | 174 | WP_038881246.1 | hypothetical protein | - |
AM681_RS18705 | 3863250..3863630 | - | 381 | WP_048234508.1 | DUF2570 family protein | - |
AM681_RS18710 | 3863627..3864028 | - | 402 | WP_038881240.1 | M15 family metallopeptidase | - |
AM681_RS18715 | 3864018..3864344 | - | 327 | WP_004936551.1 | phage holin, lambda family | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13161.95 Da Isoelectric Point: 4.9139
>T74833 WP_047730131.1 NZ_CP020503:c3860285-3859929 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE
Download Length: 357 bp
>T74833 NZ_CP020503:c3860285-3859929 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATAGTGCCTCACGGCCGCCAGGAAGGCAGAAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCTGCTAACCGAATAA
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATAGTGCCTCACGGCCGCCAGGAAGGCAGAAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCTGCTAACCGAATAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 7749.96 Da Isoelectric Point: 10.1768
>AT74833 WP_004936539.1 NZ_CP020503:c3860491-3860282 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR
Download Length: 210 bp
>AT74833 NZ_CP020503:c3860491-3860282 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTCTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTCTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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