Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1098595..1099217 Replicon chromosome
Accession NZ_CP020503
Organism Serratia marcescens strain 95

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag AM681_RS05300 Protein ID WP_004940313.1
Coordinates 1098595..1098798 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag AM681_RS05305 Protein ID WP_004940312.1
Coordinates 1098849..1099217 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM681_RS05280 1095084..1095755 + 672 WP_038876207.1 hypothetical protein -
AM681_RS05285 1095752..1096864 + 1113 WP_017145378.1 ImmA/IrrE family metallo-endopeptidase -
AM681_RS05290 1097035..1098202 - 1168 Protein_993 IS3 family transposase -
AM681_RS05300 1098595..1098798 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
AM681_RS05305 1098849..1099217 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
AM681_RS05310 1099376..1099729 - 354 WP_048232846.1 hypothetical protein -
AM681_RS05315 1100139..1100852 + 714 WP_038874977.1 ABC transporter ATP-binding protein -
AM681_RS05320 1100849..1101706 + 858 WP_038874980.1 metal ABC transporter permease -
AM681_RS05325 1101732..1102610 + 879 WP_038874983.1 zinc ABC transporter substrate-binding protein -
AM681_RS05330 1102673..1103878 - 1206 WP_075335767.1 ISL3 family transposase -
AM681_RS05335 1104035..1104175 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1091056..1099729 8673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T74823 WP_004940313.1 NZ_CP020503:c1098798-1098595 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T74823 NZ_CP020503:c1098798-1098595 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT74823 WP_004940312.1 NZ_CP020503:c1099217-1098849 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT74823 NZ_CP020503:c1099217-1098849 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
GACCTTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References