Detailed information of TA system TA074822

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 923325..923983
• Replicon: chromosome
• Accession: NZ_CP020503
• Organism: Serratia marcescens strain 95

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: AM681_RS04395
• Protein ID: WP_032637385.1
• Coordinates: 923325..923645 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: AM681_RS04400
• Protein ID: WP_032637384.1
• Coordinates: 923666..923983 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM681_RS04375	918376..919914	+	1539	WP_032637388.1	sugar ABC transporter ATP-binding protein	-
AM681_RS04380	919917..920999	+	1083	WP_006809988.1	ABC transporter permease	-
AM681_RS04385	921088..922038	+	951	WP_048232733.1	D-ribose ABC transporter substrate-binding protein	-
AM681_RS04390	922169..923026	+	858	WP_048232736.1	DeoR/GlpR family DNA-binding transcription regulator	-
AM681_RS04395	923325..923645	-	321	WP_032637385.1	TA system toxin CbtA family protein	Toxin
AM681_RS04400	923666..923983	-	318	WP_032637384.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AM681_RS04405	924002..924223	-	222	WP_032637383.1	DUF987 domain-containing protein	-
AM681_RS04410	924232..924708	-	477	WP_000811693.1	RadC family protein	-
AM681_RS04415	924724..925203	-	480	WP_015063037.1	antirestriction protein	-
AM681_RS04425	926065..928260	-	2196	WP_048232739.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-104)

Antitoxin

• Antitoxin CbeA (5-103)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12146.14 Da
• Isoelectric Point: 7.1656

>T74822 WP_032637385.1 NZ_CP020503:c923645-923325 [Serratia marcescens]
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPFITAVDILKARRAMREMRT

Nucleotide

• Length: 321 bp

>T74822 NZ_CP020503:c923645-923325 [Serratia marcescens]
ATGAAAACTCTACCCGCAACGACTTTGTGGGCGGCTAAACCATGCCCGTCACCAGTGATCGTATGGCAAATGCTTCTTTC
ACGTCTGCTGGATCAGCACTATGGCCTGACACTGAATGACACGCCATTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCTCTTTAGCCGATGCCGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGCATCGATCGTAAGGGGTTT
AGCTGGCAAGAACAGTCGCCTTTTATTACTGCTGTAGACATTCTAAAAGCCAGACGGGCTATGAGGGAAATGAGAACATA
A

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12020.58 Da
• Isoelectric Point: 6.7389

>AT74822 WP_032637384.1 NZ_CP020503:c923983-923666 [Serratia marcescens]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHAHCVTLYH
NGFTCEADTLGSCGYVYITVYPTHR

Nucleotide

• Length: 318 bp

>AT74822 NZ_CP020503:c923983-923666 [Serratia marcescens]
ATGAGCAACATTACATGGGGGCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGTAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGCCATGCCCACTGCGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCACCGTTTATCCCACTCACCGATAA