Detailed information of TA system TA074819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 171354..171826
• Replicon: chromosome
• Accession: NZ_CP020503
• Organism: Serratia marcescens strain 95

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5P6GNV0
• Locus tag: AM681_RS00805
• Protein ID: WP_048232401.1
• Coordinates: 171551..171826 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AM681_RS00800
• Protein ID: WP_033649649.1
• Coordinates: 171354..171551 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM681_RS00770	166542..167810	+	1269	WP_048232394.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-
AM681_RS00775	167807..169006	+	1200	WP_048232396.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
AM681_RS00780	169042..169605	-	564	WP_047729417.1	DcrB family lipoprotein	-
AM681_RS00785	169686..170120	-	435	WP_048232398.1	GNAT family N-acetyltransferase	-
AM681_RS00790	170167..170826	-	660	WP_047729415.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
AM681_RS00795	171047..171292	+	246	WP_025304890.1	sulfurtransferase TusA	-
AM681_RS00800	171354..171551	+	198	WP_033649649.1	hypothetical protein	Antitoxin
AM681_RS00805	171551..171826	+	276	WP_048232401.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
AM681_RS00810	171886..174204	-	2319	WP_048232403.1	zinc/cadmium/mercury/lead-transporting ATPase	-
AM681_RS00815	174887..176350	+	1464	WP_038874135.1	serralysin family metalloprotease	-
AM681_RS00820	176406..176783	+	378	WP_038874139.1	AprI/Inh family metalloprotease inhibitor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10666.57 Da
• Isoelectric Point: 11.2806

>T74819 WP_048232401.1 NZ_CP020503:171551-171826 [Serratia marcescens]
MLNIEWTRVARQDLGEIVGFIANDNPLAARKMKALIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T74819 NZ_CP020503:171551-171826 [Serratia marcescens]
ATGCTCAACATCGAATGGACTCGAGTCGCACGTCAGGATCTGGGGGAGATTGTGGGATTTATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGCTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTGCATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7398.49 Da
• Isoelectric Point: 4.4143

>AT74819 WP_033649649.1 NZ_CP020503:171354-171551 [Serratia marcescens]
MSILLLPTVAKMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Nucleotide

• Length: 198 bp

>AT74819 NZ_CP020503:171354-171551 [Serratia marcescens]
ATGAGTATTTTACTGCTGCCTACGGTTGCCAAGATGGAAAATGAGGAGCGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCACGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Structures

Toxin

• AlphaFold DB: A0A5P6GNV0