Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 15055..15656 | Replicon | chromosome |
Accession | NZ_CP020503 | ||
Organism | Serratia marcescens strain 95 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | AM681_RS00090 | Protein ID | WP_038876000.1 |
Coordinates | 15055..15435 (-) | Length | 127 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A0G3SPC0 |
Locus tag | AM681_RS00095 | Protein ID | WP_038875999.1 |
Coordinates | 15435..15656 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM681_RS00055 | 10843..11190 | - | 348 | WP_016929593.1 | YceK/YidQ family lipoprotein | - |
AM681_RS00060 | 11500..11790 | + | 291 | WP_080347946.1 | Hsp20 family protein | - |
AM681_RS00070 | 11841..12538 | + | 698 | Protein_11 | IS1 family transposase | - |
AM681_RS00075 | 12555..12689 | + | 135 | Protein_12 | Hsp20 family protein | - |
AM681_RS00080 | 12790..13218 | + | 429 | WP_004933922.1 | heat shock chaperone IbpB | - |
AM681_RS00085 | 13386..15044 | + | 1659 | WP_047729572.1 | putative transporter | - |
AM681_RS00090 | 15055..15435 | - | 381 | WP_038876000.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
AM681_RS00095 | 15435..15656 | - | 222 | WP_038875999.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
AM681_RS00100 | 15731..16981 | - | 1251 | WP_038875998.1 | valine--pyruvate transaminase | - |
AM681_RS00105 | 17117..19180 | - | 2064 | WP_048232293.1 | alpha-amylase | - |
AM681_RS27710 | 19376..19528 | + | 153 | WP_171887318.1 | hypothetical protein | - |
AM681_RS00110 | 19530..20507 | - | 978 | WP_048232294.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 12035..12538 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14167.50 Da Isoelectric Point: 7.3170
>T74818 WP_038876000.1 NZ_CP020503:c15435-15055 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVIVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVIVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL
Download Length: 381 bp
>T74818 NZ_CP020503:c15435-15055 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATAGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATAGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8563.50 Da Isoelectric Point: 4.4791
>AT74818 WP_038875999.1 NZ_CP020503:c15656-15435 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE
Download Length: 222 bp
>AT74818 NZ_CP020503:c15656-15435 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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