Detailed information of TA system TA074783

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4664145..4664980
• Replicon: chromosome
• Accession: NZ_CP020495
• Organism: Escherichia coli strain 103

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0J1YPH7
• Locus tag: CPA47_RS23175
• Protein ID: WP_029701676.1
• Coordinates: 4664603..4664980 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A0K5N986
• Locus tag: CPA47_RS23170
• Protein ID: WP_021553056.1
• Coordinates: 4664145..4664513 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPA47_RS23135	4659807..4660487	+	681	WP_029702103.1	WYL domain-containing protein	-
CPA47_RS23140	4660635..4661312	+	678	WP_001097302.1	hypothetical protein	-
CPA47_RS23145	4661318..4661551	+	234	WP_001278293.1	DUF905 family protein	-
CPA47_RS23150	4661641..4662459	+	819	WP_001175165.1	DUF945 domain-containing protein	-
CPA47_RS23155	4662725..4663204	+	480	WP_001564060.1	antirestriction protein	-
CPA47_RS23160	4663220..4663696	+	477	WP_021553055.1	RadC family protein	-
CPA47_RS23165	4663761..4663982	+	222	WP_000692345.1	DUF987 domain-containing protein	-
CPA47_RS23170	4664145..4664513	+	369	WP_021553056.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CPA47_RS23175	4664603..4664980	+	378	WP_029701676.1	TA system toxin CbtA family protein	Toxin
CPA47_RS23180	4664977..4665126	+	150	Protein_4436	hypothetical protein	-
CPA47_RS23185	4665205..4665399	+	195	WP_024181941.1	DUF957 domain-containing protein	-
CPA47_RS23190	4665484..4666326	+	843	WP_022645115.1	DUF4942 domain-containing protein	-
CPA47_RS23195	4667075..4668613	+	1539	WP_001187196.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4630607..4676425	45818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14066.04 Da
• Isoelectric Point: 7.8045

>T74783 WP_029701676.1 NZ_CP020495:4664603-4664980 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Nucleotide

• Length: 378 bp

>T74783 NZ_CP020495:4664603-4664980 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13615.39 Da
• Isoelectric Point: 7.0264

>AT74783 WP_021553056.1 NZ_CP020495:4664145-4664513 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT74783 NZ_CP020495:4664145-4664513 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0J1YPH7

Antitoxin

• AlphaFold DB: A0A0K5N986