Detailed information of TA system TA074780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4385823..4386637
• Replicon: chromosome
• Accession: NZ_CP020495
• Organism: Escherichia coli strain 103

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: CPA47_RS21595
• Protein ID: WP_001054376.1
• Coordinates: 4385823..4386080 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: CPA47_RS21600
• Protein ID: WP_001309181.1
• Coordinates: 4386092..4386637 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPA47_RS21575	4381111..4382217	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
CPA47_RS21580	4382282..4383262	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
CPA47_RS21585	4383845..4385085	-	1241	Protein_4148	helicase YjhR	-
CPA47_RS21590	4385201..4385446	+	246	Protein_4149	GNAT family N-acetyltransferase	-
CPA47_RS21595	4385823..4386080	+	258	WP_001054376.1	hypothetical protein	Toxin
CPA47_RS21600	4386092..4386637	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
CPA47_RS21605	4386693..4387439	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
CPA47_RS21610	4387608..4387826	+	219	Protein_4153	hypothetical protein	-
CPA47_RS26870	4387864..4387980	+	117	Protein_4154	VOC family protein	-
CPA47_RS21615	4388225..4389346	+	1122	WP_000010829.1	M42 family metallopeptidase	-
CPA47_RS21620	4389343..4389621	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
CPA47_RS21625	4389633..4390946	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4378317..4394861	16544

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T74780 WP_001054376.1 NZ_CP020495:4385823-4386080 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T74780 NZ_CP020495:4385823-4386080 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT74780 WP_001309181.1 NZ_CP020495:4386092-4386637 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT74780 NZ_CP020495:4386092-4386637 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8