Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2561433..2562406 Replicon chromosome
Accession NZ_CP020477
Organism Acidianus manzaensis strain YN-25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B6F84_RS13295 Protein ID WP_148692692.1
Coordinates 2561795..2562406 (+) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B6F84_RS13290 Protein ID WP_148692691.1
Coordinates 2561433..2561798 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6F84_RS13270 (B6F84_13260) 2557321..2558445 - 1125 WP_148692688.1 radical SAM protein -
B6F84_RS13275 (B6F84_13265) 2558570..2559268 - 699 WP_148692689.1 hypothetical protein -
B6F84_RS13280 (B6F84_13270) 2559662..2559976 + 315 WP_148691985.1 4Fe-4S binding protein -
B6F84_RS13285 (B6F84_13275) 2560344..2561399 + 1056 WP_148692690.1 nitric oxide response protein -
B6F84_RS13290 (B6F84_13280) 2561433..2561798 + 366 WP_148692691.1 DUF488 domain-containing protein Antitoxin
B6F84_RS13295 (B6F84_13285) 2561795..2562406 + 612 WP_148692692.1 helix-turn-helix domain-containing protein Toxin
B6F84_RS13945 2562619..2562759 - 141 WP_187152707.1 hypothetical protein -
B6F84_RS13300 (B6F84_13290) 2563764..2564195 + 432 WP_148692693.1 cation-binding protein -
B6F84_RS13305 (B6F84_13295) 2564162..2564596 - 435 Protein_2633 transposase -
B6F84_RS13310 2564600..2564858 + 259 Protein_2634 transposase -
B6F84_RS13315 (B6F84_13305) 2564860..2565429 - 570 Protein_2635 helix-turn-helix domain-containing protein -
B6F84_RS13320 (B6F84_13310) 2565443..2565721 - 279 WP_236748979.1 IS200/IS605 family transposase -
B6F84_RS13325 (B6F84_13315) 2566181..2567248 - 1068 WP_148692694.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(144-196)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 23027.02 Da        Isoelectric Point: 8.2393

>T74734 WP_148692692.1 NZ_CP020477:2561795-2562406 [Acidianus manzaensis]
MKKSPLEASIVIENHPCEVMKLISSLNLNAFVENVKLGDNVTDHIVNFDDLDNTQYQKLRLASLKTMRLSDSKVWIRTSG
CAVCKLLYSSDVVVEKVKVVGEKALIYNLLIPNMSSLKDLLKKLNDIGVKSTVMSIMEIEENQLTERQMEILKMAFKLGY
FDDDRKISMSELAEKLGISAPTLEEILRRALRKVVKNYLDKSS

Download         Length: 612 bp

>T74734 NZ_CP020477:2561795-2562406 [Acidianus manzaensis]
ATGAAGAAATCTCCTCTAGAAGCGAGTATAGTAATAGAAAACCATCCATGCGAAGTTATGAAATTAATTTCATCGCTTAA
CCTAAACGCATTTGTAGAAAATGTAAAACTAGGAGACAATGTTACAGATCATATAGTTAATTTTGATGATTTAGATAATA
CTCAATATCAAAAATTAAGATTAGCATCATTAAAAACTATGAGACTTAGTGATAGTAAAGTGTGGATAAGAACGAGTGGT
TGTGCTGTATGTAAACTTCTTTACTCATCAGATGTTGTTGTTGAAAAAGTAAAAGTAGTAGGAGAAAAAGCATTAATCTA
TAATCTTTTAATTCCCAATATGAGCTCATTAAAAGATTTATTGAAAAAACTAAACGATATAGGAGTAAAATCTACGGTTA
TGAGCATAATGGAAATAGAAGAAAATCAGCTTACAGAAAGACAAATGGAAATATTGAAGATGGCTTTTAAATTAGGATAT
TTTGATGATGATAGGAAAATTTCAATGTCAGAATTAGCTGAGAAGTTAGGTATAAGTGCGCCAACTTTAGAGGAAATACT
TAGAAGAGCCTTAAGAAAAGTAGTCAAGAATTATCTGGACAAAAGTAGTTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 14498.79 Da        Isoelectric Point: 9.5926

>AT74734 WP_148692691.1 NZ_CP020477:2561433-2561798 [Acidianus manzaensis]
MIKIKRIYDPIEKDDGLRILVDRLWPRGVKKDRIDLWLKEIAPSEELRKWFNHDPEKWEEFKKKYFEELNQNPKLSGLLK
LVKDGNNVTLLYATTSPYNNAVALKEFLEKRLLNEEEKKNA

Download         Length: 366 bp

>AT74734 NZ_CP020477:2561433-2561798 [Acidianus manzaensis]
ATGATAAAAATAAAGAGGATTTATGATCCTATAGAAAAAGATGATGGATTGAGGATACTAGTTGATAGACTATGGCCTAG
AGGAGTTAAAAAAGATAGGATTGATCTTTGGTTAAAGGAAATTGCTCCGTCAGAAGAATTAAGGAAATGGTTTAATCATG
ATCCAGAGAAATGGGAAGAATTTAAGAAGAAATACTTTGAGGAATTGAATCAAAATCCTAAATTGTCTGGTTTGTTGAAG
TTAGTAAAAGACGGAAACAATGTGACATTACTATACGCAACCACTTCACCTTATAATAATGCTGTGGCATTAAAGGAGTT
TTTAGAAAAAAGATTATTAAATGAAGAAGAAAAGAAAAATGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References