Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 86943..87564 Replicon chromosome
Accession NZ_CP020477
Organism Acidianus manzaensis strain YN-25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B6F84_RS00210 Protein ID WP_148690350.1
Coordinates 86943..87350 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B6F84_RS00215 Protein ID WP_148690351.1
Coordinates 87340..87564 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6F84_RS00200 (B6F84_00210) 83207..84799 + 1593 WP_148690349.1 ankyrin repeat domain-containing protein -
B6F84_RS00205 (B6F84_00215) 85426..86604 + 1179 WP_148692778.1 carboxypeptidase CpsA -
B6F84_RS00210 (B6F84_00220) 86943..87350 - 408 WP_148690350.1 PIN domain-containing protein Toxin
B6F84_RS00215 (B6F84_00225) 87340..87564 - 225 WP_148690351.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
B6F84_RS00220 (B6F84_00230) 87791..89110 + 1320 WP_187152717.1 AAA family ATPase -
B6F84_RS00225 (B6F84_00235) 89413..90474 - 1062 WP_148690353.1 DUF5808 domain-containing protein -
B6F84_RS00230 (B6F84_00240) 90471..90839 - 369 WP_148690354.1 GntR family transcriptional regulator -
B6F84_RS00235 (B6F84_00245) 91361..92041 - 681 WP_148690355.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-118)

Antitoxin

Post-segregation antitoxin CcdA

(5-55)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15781.45 Da        Isoelectric Point: 6.4159

>T74733 WP_148690350.1 NZ_CP020477:c87350-86943 [Acidianus manzaensis]
MKDKYLFDTSALYPLIIELLRGKINLNFLSNAYILDLTIYEIGNVLWKESKIKNKIKDPVETMQNFLKIIEKFNLITEID
YTKVLKLAIERNLTFYDSAYVYIAEENNLTLVTYDKELLGKTKNAKTLDEIISKS

Download         Length: 408 bp

>T74733 NZ_CP020477:c87350-86943 [Acidianus manzaensis]
ATGAAAGATAAATATCTCTTTGATACTTCAGCACTATATCCACTAATTATAGAACTATTAAGAGGAAAAATAAATCTCAA
CTTCCTTTCAAACGCTTATATTCTTGACTTGACAATTTACGAAATCGGTAACGTCTTATGGAAAGAAAGTAAAATCAAAA
ATAAAATAAAAGATCCAGTAGAAACAATGCAAAACTTTCTTAAAATAATAGAAAAATTCAATTTAATAACCGAAATCGAT
TACACCAAAGTATTAAAATTAGCAATTGAAAGAAACTTAACATTCTACGACAGCGCATACGTTTACATAGCAGAAGAAAA
CAACCTAACTCTAGTAACTTACGATAAAGAATTATTAGGAAAAACAAAAAACGCAAAAACACTAGACGAAATTATAAGTA
AGTCTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8845.23 Da        Isoelectric Point: 5.9610

>AT74733 WP_148690351.1 NZ_CP020477:c87564-87340 [Acidianus manzaensis]
MSDVISVRVRKQLKEKAEKLGIDIRQVVEKALEEEIKKKEEEEIKKSAEIIAENMKEVKIEEWTHLVRETRNER

Download         Length: 225 bp

>AT74733 NZ_CP020477:c87564-87340 [Acidianus manzaensis]
ATGTCTGACGTTATCTCTGTTAGAGTCAGAAAGCAACTAAAAGAGAAAGCCGAAAAATTAGGAATAGATATAAGGCAAGT
AGTAGAAAAAGCCCTAGAAGAAGAAATCAAGAAAAAAGAAGAAGAAGAAATAAAAAAATCAGCAGAAATAATAGCAGAAA
ACATGAAAGAAGTTAAAATAGAAGAATGGACACATCTAGTGAGAGAAACCAGAAATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References