Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 807182..807766 Replicon chromosome
Accession NZ_CP020468
Organism Actinomyces gaoshouyii strain pika_114

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B6G06_RS03250 Protein ID WP_080463098.1
Coordinates 807404..807766 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B6G06_RS03245 Protein ID WP_080463099.1
Coordinates 807182..807391 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6G06_RS03230 802507..802698 - 192 WP_017178316.1 50S ribosomal protein L28 -
B6G06_RS03235 802930..804744 + 1815 WP_081170957.1 DAK2 domain-containing protein -
B6G06_RS03240 804853..807132 + 2280 WP_081172176.1 ATP-dependent DNA helicase RecG -
B6G06_RS03245 807182..807391 + 210 WP_080463099.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B6G06_RS03250 807404..807766 + 363 WP_080463098.1 type II toxin-antitoxin system VapC family toxin Toxin
B6G06_RS03255 807811..808386 - 576 WP_080463097.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
B6G06_RS03260 808488..809063 + 576 WP_188640744.1 pantetheine-phosphate adenylyltransferase -
B6G06_RS03265 809066..809599 + 534 WP_080463096.1 ATPase -
B6G06_RS03270 809704..810261 + 558 WP_080463095.1 DUF177 domain-containing protein -
B6G06_RS03275 810261..811091 + 831 WP_081170959.1 ribonuclease III -
B6G06_RS03280 811097..812137 + 1041 WP_081170961.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13220.22 Da        Isoelectric Point: 6.4801

>T74727 WP_080463098.1 NZ_CP020468:807404-807766 [Actinomyces gaoshouyii]
MILVDTNVWIDHLHASETRLVGLLESALVATHEAVLTELALGSLKNRQDVLDSLASLRRVPRISDGEVRWFVERRCLWGR
GLSAVDAHLLASAVAVPGTLLWTRDRRLAVAADELGVGYQ

Download         Length: 363 bp

>T74727 NZ_CP020468:807404-807766 [Actinomyces gaoshouyii]
ATGATCCTCGTCGACACCAACGTGTGGATCGACCACTTGCACGCCAGTGAGACTCGCCTCGTCGGCCTCCTCGAAAGCGC
TCTGGTCGCCACCCATGAAGCGGTGCTCACCGAACTGGCGCTCGGATCGCTCAAGAACCGGCAGGACGTCCTCGACTCCC
TGGCGTCCCTACGACGAGTGCCCCGTATCTCTGATGGGGAGGTTCGCTGGTTCGTTGAACGCCGTTGCCTGTGGGGAAGA
GGCCTATCAGCAGTTGATGCGCACCTGCTCGCATCCGCCGTCGCCGTGCCTGGCACGCTGTTGTGGACCAGGGACAGGCG
TCTTGCGGTCGCCGCCGACGAACTCGGGGTCGGCTATCAATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7742.80 Da        Isoelectric Point: 7.0145

>AT74727 WP_080463099.1 NZ_CP020468:807182-807391 [Actinomyces gaoshouyii]
MRTTITLDDDLLERATELTGITERAALVREAVSTLIRVESSRRLIALGGTDLTAEAAPRHRDLRVQRDR

Download         Length: 210 bp

>AT74727 NZ_CP020468:807182-807391 [Actinomyces gaoshouyii]
ATGCGCACCACGATCACACTTGACGACGATCTTCTGGAACGAGCCACTGAGCTGACGGGTATCACCGAGAGAGCTGCTCT
TGTGAGGGAGGCGGTCAGCACCCTCATCAGAGTCGAGAGCTCGCGGCGCCTGATCGCCCTCGGGGGCACCGATCTCACCG
CCGAGGCGGCCCCGAGGCATCGGGACTTGCGAGTCCAGCGGGATCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References