74721

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2199413..2199927 Replicon chromosome
Accession NZ_CP020467
Organism Staphylococcus aureus strain CFSAN007896

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag AB477_RS11310 Protein ID WP_000581791.1
Coordinates 2199413..2199622 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag AB477_RS11315 Protein ID WP_000138934.1
Coordinates 2199634..2199927 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB477_RS11290 2195302..2196372 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
AB477_RS11295 2196690..2197892 + 1203 WP_001109939.1 rod shape-determining protein RodA -
AB477_RS11300 2198053..2198736 - 684 Protein_2101 transposase -
AB477_RS11305 2199148..2199285 - 138 WP_000828354.1 hypothetical protein -
AB477_RS11310 2199413..2199622 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
AB477_RS11315 2199634..2199927 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
AB477_RS11320 2200093..2201577 + 1485 WP_000571560.1 cardiolipin synthase -
AB477_RS11325 2201605..2202252 + 648 WP_001187612.1 HD domain-containing protein -
AB477_RS11335 2202409..2202708 + 300 WP_001793952.1 hypothetical protein -
AB477_RS11340 2202865..2203737 - 873 WP_000725802.1 membrane protein insertase YidC -
AB477_RS11345 2203823..2204464 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2198053..2198229 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T74721 WP_000581791.1 NZ_CP020467:c2199622-2199413 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T74721 NZ_CP020467:c2199622-2199413 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT74721 WP_000138934.1 NZ_CP020467:c2199927-2199634 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT74721 NZ_CP020467:c2199927-2199634 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References