Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1580994..1581782 Replicon chromosome
Accession NZ_CP020467
Organism Staphylococcus aureus strain CFSAN007896

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag AB477_RS07830 Protein ID WP_000525004.1
Coordinates 1581321..1581782 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag AB477_RS07825 Protein ID WP_000333630.1
Coordinates 1580994..1581308 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB477_RS07775 1576534..1577700 - 1167 WP_031834538.1 DUF2800 domain-containing protein -
AB477_RS07780 1577697..1578059 - 363 WP_000985976.1 hypothetical protein -
AB477_RS07785 1578074..1578397 - 324 WP_000174994.1 hypothetical protein -
AB477_RS07790 1578476..1578637 - 162 WP_001285954.1 DUF1270 domain-containing protein -
AB477_RS07795 1578650..1578913 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
AB477_RS07800 1578938..1579153 - 216 WP_001097552.1 hypothetical protein -
AB477_RS07805 1579208..1579573 + 366 WP_001128433.1 hypothetical protein -
AB477_RS07810 1579542..1579787 - 246 WP_001025401.1 DUF2829 domain-containing protein -
AB477_RS07815 1579816..1580592 - 777 WP_001148544.1 Rha family transcriptional regulator -
AB477_RS07820 1580606..1580842 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
AB477_RS07825 1580994..1581308 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
AB477_RS07830 1581321..1581782 + 462 WP_000525004.1 hypothetical protein Toxin
AB477_RS07835 1581800..1582384 + 585 WP_000825948.1 hypothetical protein -
AB477_RS07840 1582723..1583346 - 624 WP_001166482.1 hypothetical protein -
AB477_RS07845 1583456..1584661 + 1206 WP_000264191.1 site-specific integrase -
AB477_RS07850 1584704..1586746 - 2043 WP_001794062.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1538106..1602311 64205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T74713 WP_000525004.1 NZ_CP020467:1581321-1581782 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T74713 NZ_CP020467:1581321-1581782 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT74713 WP_000333630.1 NZ_CP020467:1580994-1581308 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT74713 NZ_CP020467:1580994-1581308 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References