74708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 849782..850259 Replicon chromosome
Accession NZ_CP020467
Organism Staphylococcus aureus strain CFSAN007896

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AB477_RS04170 Protein ID WP_000052076.1
Coordinates 849782..849970 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AB477_RS04175 Protein ID WP_001059690.1
Coordinates 849999..850259 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB477_RS04140 845735..846292 + 558 WP_000824491.1 hypothetical protein -
AB477_RS04145 846633..847319 + 687 WP_001574556.1 thermonuclease family protein -
AB477_RS04150 847676..847876 + 201 WP_001059082.1 cold-shock protein -
AB477_RS04155 848373..848591 - 219 WP_000005879.1 hypothetical protein -
AB477_RS04160 848653..848937 - 285 WP_001004401.1 hypothetical protein -
AB477_RS04165 849025..849594 - 570 WP_107375201.1 hypothetical protein -
AB477_RS04170 849782..849970 - 189 WP_000052076.1 hypothetical protein Toxin
AB477_RS04175 849999..850259 - 261 WP_001059690.1 hypothetical protein Antitoxin
AB477_RS04180 850600..850803 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AB477_RS04185 850800..851036 - 237 WP_000368687.1 hypothetical protein -
AB477_RS04190 851261..851842 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
AB477_RS04195 851915..852532 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
AB477_RS04200 852688..853182 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AB477_RS04205 853581..854003 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
AB477_RS04210 854151..854867 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

DNA binding HTH domain, AraC-type

(197-274)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T74708 WP_000052076.1 NZ_CP020467:c849970-849782 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T74708 NZ_CP020467:c849970-849782 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT74708 WP_001059690.1 NZ_CP020467:c850259-849999 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT74708 NZ_CP020467:c850259-849999 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References