Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 828791..829320 Replicon chromosome
Accession NZ_CP020463
Organism Staphylococcus epidermidis strain 1457

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag B4U56_RS04090 Protein ID WP_001829891.1
Coordinates 828958..829320 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag B4U56_RS04085 Protein ID WP_001829931.1
Coordinates 828791..828961 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4U56_RS04060 824615..825094 + 480 WP_002457111.1 PH domain-containing protein -
B4U56_RS04065 825087..826592 + 1506 WP_002457110.1 PH domain-containing protein -
B4U56_RS04070 826579..827088 + 510 WP_002457109.1 PH domain-containing protein -
B4U56_RS04075 827136..827489 + 354 WP_002457108.1 holo-ACP synthase -
B4U56_RS04080 827556..828704 + 1149 WP_002457107.1 alanine racemase -
B4U56_RS04085 828791..828961 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
B4U56_RS04090 828958..829320 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
B4U56_RS04095 829665..830666 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
B4U56_RS04100 830766..831092 + 327 WP_001829952.1 anti-sigma factor antagonist -
B4U56_RS04105 831094..831573 + 480 WP_001829903.1 anti-sigma B factor RsbW -
B4U56_RS04110 831548..832318 + 771 WP_032606413.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T74699 WP_001829891.1 NZ_CP020463:828958-829320 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T74699 NZ_CP020463:828958-829320 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT74699 WP_001829931.1 NZ_CP020463:828791-828961 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT74699 NZ_CP020463:828791-828961 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References