Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1861489..1861948 Replicon chromosome
Accession NZ_CP020451
Organism Streptococcus salivarius strain FDAARGOS_259

Toxin (Protein)


Gene name relE Uniprot ID A0A1V0H9I6
Locus tag A6J87_RS08955 Protein ID WP_060973029.1
Coordinates 1861694..1861948 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8LI53
Locus tag A6J87_RS08950 Protein ID WP_013990356.1
Coordinates 1861489..1861704 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J87_RS08940 1859346..1860419 + 1074 WP_080612075.1 hypothetical protein -
A6J87_RS08945 1860513..1861355 + 843 WP_048790042.1 aldo/keto reductase -
A6J87_RS08950 1861489..1861704 + 216 WP_013990356.1 hypothetical protein Antitoxin
A6J87_RS08955 1861694..1861948 + 255 WP_060973029.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J87_RS08960 1862093..1862779 + 687 WP_004182263.1 DUF1275 domain-containing protein -
A6J87_RS08965 1862870..1863502 + 633 WP_080611924.1 nitroreductase family protein -
A6J87_RS08970 1863690..1864982 + 1293 WP_073687034.1 PTS sugar transporter subunit IIC -
A6J87_RS08975 1864969..1865832 + 864 WP_070438109.1 alpha/beta hydrolase -
A6J87_RS08980 1866011..1866460 + 450 WP_080611925.1 Rrf2 family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-57)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9889.63 Da        Isoelectric Point: 11.1183

>T74697 WP_060973029.1 NZ_CP020451:1861694-1861948 [Streptococcus salivarius]
MTYKIVPTPKFAKNFKKLDPFVRKQIKSYLNRVTDNPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Download         Length: 255 bp

>T74697 NZ_CP020451:1861694-1861948 [Streptococcus salivarius]
ATGACCTATAAGATAGTACCCACCCCTAAATTTGCCAAAAATTTTAAAAAGTTGGATCCTTTCGTCAGAAAACAAATTAA
GTCTTATCTCAATCGTGTCACAGATAATCCAAGAGCCAAGGGTAAGGCCTTGGTTGCCAATCGCACTGGACAATGGCGCT
ATCGTATTGGTGCCTATCGTGTTATTGTCAATATTCAGGACAATGAACTAATCATACTTGCCCTCGAAGTCGGTCATAGA
CGTGATATCTATTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8016.98 Da        Isoelectric Point: 3.8852

>AT74697 WP_013990356.1 NZ_CP020451:1861489-1861704 [Streptococcus salivarius]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLDAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Download         Length: 216 bp

>AT74697 NZ_CP020451:1861489-1861704 [Streptococcus salivarius]
ATGACAACAATTACATTGAAGGTTTCAGAGGCAGATAAGAAGTTCATGCAGGCCATTGCGAAATTCGAAGGCGTATCCTT
GTCAGAATTAATTCGTACCAAGACTTTAGACGCTATTGAGGATGAATACGATGCTAGAGTAGCCGATTTGGCTTTGGCAG
AATATGAAGACTATCTTGAAAACGGTGGGGAGGTGCTAAATTGGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0H9I6

Antitoxin

Source ID Structure
AlphaFold DB F8LI53

References