Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 386631..387874 Replicon chromosome
Accession NZ_CP020450
Organism Streptococcus gordonii strain FDAARGOS_257

Toxin (Protein)


Gene name sezT Uniprot ID A0A1V0H0B3
Locus tag A6J85_RS01940 Protein ID WP_046165029.1
Coordinates 386631..387398 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A1V0H0A0
Locus tag A6J85_RS01945 Protein ID WP_061601558.1
Coordinates 387398..387874 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J85_RS01900 381958..382128 - 171 WP_103344441.1 thiazolylpeptide-type bacteriocin -
A6J85_RS01905 382483..383811 - 1329 WP_048778126.1 GHKL domain-containing protein -
A6J85_RS01910 383824..384558 - 735 WP_048778123.1 LytTR family DNA-binding domain-containing protein -
A6J85_RS01920 385228..385359 + 132 Protein_363 site-specific integrase -
A6J85_RS01925 385738..386109 - 372 WP_046165031.1 type II toxin-antitoxin system death-on-curing family toxin -
A6J85_RS01930 386106..386363 - 258 WP_046165030.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A6J85_RS01940 386631..387398 - 768 WP_046165029.1 zeta toxin family protein Toxin
A6J85_RS01945 387398..387874 - 477 WP_061601558.1 helix-turn-helix domain-containing protein Antitoxin
A6J85_RS01950 388024..388546 + 523 Protein_368 SPASM domain-containing protein -
A6J85_RS01955 388530..390047 + 1518 WP_061601559.1 ABC transporter ATP-binding protein/permease -
A6J85_RS01965 390765..391085 - 321 WP_002893753.1 hypothetical protein -
A6J85_RS01975 391297..391635 - 339 WP_000711078.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
A6J85_RS01980 391647..392273 - 627 WP_071788354.1 CadD family cadmium resistance transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 368626..404461 35835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29212.13 Da        Isoelectric Point: 6.8457

>T74694 WP_046165029.1 NZ_CP020450:c387398-386631 [Streptococcus gordonii]
MKLEEFSQDDFERASRRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKQGYHLLIEGTLRTTEVPRKTAQLLITKGYQVSLALIATKPELSYLSTLIRYEE
LYAIDSSQARATPKAHHDGIVEHMVDNLRELENDKLFRQIQIYQRDQSCVYDSQVDETSATEVLHECLFGKWSKVEEEML
KLGQERLREMGGINK

Download         Length: 768 bp

>T74694 NZ_CP020450:c387398-386631 [Streptococcus gordonii]
ATGAAACTAGAAGAATTTAGTCAAGATGATTTTGAACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACTTCGTCTCAGCCCAAGGCTATCTTGCTAGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGAGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCTTACAGGAA
AAGTATGGAAAAGATAGTGTGGATTATACCAAAGTATTCGCGGGACAAATGGTTGAATATCTCGTAGATGAATTGAGTAA
ACAAGGTTATCATTTGTTAATCGAGGGCACCTTGAGAACAACAGAAGTTCCTAGAAAAACGGCACAATTATTGATAACTA
AAGGATATCAAGTCTCACTTGCACTAATAGCGACCAAGCCAGAATTGTCCTATCTCAGTACTTTGATACGTTATGAGGAG
CTCTACGCCATAGATTCTAGTCAAGCTAGAGCAACTCCTAAAGCACACCATGATGGAATTGTAGAACATATGGTTGATAA
CTTACGGGAGTTAGAAAATGATAAACTTTTTAGACAAATTCAAATTTATCAAAGAGATCAATCGTGTGTTTATGATTCGC
AAGTAGACGAAACCTCAGCAACAGAAGTTCTACACGAATGCCTATTTGGAAAATGGAGTAAGGTGGAGGAAGAGATGTTG
AAGTTGGGACAGGAACGGTTGAGAGAGATGGGGGGAATTAATAAGTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18125.63 Da        Isoelectric Point: 4.4008

>AT74694 WP_061601558.1 NZ_CP020450:c387874-387398 [Streptococcus gordonii]
MIGENIKALRKTHDLTQPEFAKIVGISRNSLSRYENGTSSISTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRLQDELEIAFDDANNPWVLISDDLSDLINTKIYLVATFEDVERYNGYLDGIERMLEQARHLVVA

Download         Length: 477 bp

>AT74694 NZ_CP020450:c387874-387398 [Streptococcus gordonii]
ATGATAGGAGAAAATATTAAAGCGTTACGTAAAACACATGATCTAACCCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGCCTAAGTCGTTATGAAAACGGGACAAGTTCAATTTCGACAGAATTAATAGATCGTATTTGTCAGAAATTTA
ATGTTTCCTATATCGATATTGTAGGAGAGGAAAAGATGCTCACGCCAGTGGAAGATTACCAGCTCACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTACAAGATGAACTAGAAATTGCATTTGATGATGC
TAATAATCCTTGGGTTCTAATAAGCGATGATCTTTCTGATTTGATTAACACGAAGATTTATCTTGTTGCAACTTTTGAGG
ATGTGGAGCGATATAATGGCTATTTGGATGGCATTGAACGTATGTTAGAACAAGCTCGTCATCTGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0H0B3

Antitoxin

Source ID Structure
AlphaFold DB A0A1V0H0A0

References