Detailed information of TA system TA074693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 419891..420515
• Replicon: chromosome
• Accession: NZ_CP020449
• Organism: Streptococcus agalactiae strain FDAARGOS_254

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: A6J82_RS02455
• Protein ID: WP_000253103.1
• Coordinates: 420168..420515 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: A6J82_RS02450
• Protein ID: WP_000543070.1
• Coordinates: 419891..420178 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J82_RS02415	415052..415909	+	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-
A6J82_RS02420	415921..417315	+	1395	WP_000656430.1	hypothetical protein	-
A6J82_RS02425	417608..417865	+	258	WP_001069293.1	hypothetical protein	-
A6J82_RS02430	417862..418035	+	174	WP_000694573.1	hypothetical protein	-
A6J82_RS02435	418193..418750	+	558	WP_001258765.1	hypothetical protein	-
A6J82_RS02440	418823..419311	+	489	WP_000891152.1	hypothetical protein	-
A6J82_RS11505	419318..419470	+	153	Protein_400	DUF1492 domain-containing protein	-
A6J82_RS02445	419445..419822	+	378	WP_000038826.1	DUF1492 domain-containing protein	-
A6J82_RS02450	419891..420178	+	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
A6J82_RS02455	420168..420515	+	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6J82_RS02460	420998..421294	+	297	WP_001052251.1	DUF4298 domain-containing protein	-
A6J82_RS02465	421380..421919	-	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
A6J82_RS02470	422058..424376	+	2319	WP_000883426.1	YhgE/Pip domain-containing protein	-
A6J82_RS02475	424443..424799	+	357	WP_000105934.1	DUF1304 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	404016..421294	17278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T74693 WP_000253103.1 NZ_CP020449:420168-420515 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T74693 NZ_CP020449:420168-420515 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT74693 WP_000543070.1 NZ_CP020449:419891-420178 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT74693 NZ_CP020449:419891-420178 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5