Detailed information of TA system TA074692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 160849..161457
• Replicon: chromosome
• Accession: NZ_CP020449
• Organism: Streptococcus agalactiae strain FDAARGOS_254

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I0S7M8
• Locus tag: A6J82_RS00905
• Protein ID: WP_003038349.1
• Coordinates: 161266..161457 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: A6J82_RS00900
• Protein ID: WP_041326065.1
• Coordinates: 160849..161229 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J82_RS00890	156917..159214	-	2298	WP_000472390.1	penicillin-binding protein PBP1B	-
A6J82_RS00895	159325..160584	+	1260	WP_041326067.1	tyrosine--tRNA ligase	-
A6J82_RS00900	160849..161229	-	381	WP_041326065.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A6J82_RS00905	161266..161457	-	192	WP_003038349.1	type II toxin-antitoxin system HicA family toxin	Toxin
A6J82_RS00915	162236..162571	-	336	WP_041326062.1	hypothetical protein	-
A6J82_RS00920	162571..163149	-	579	WP_024053142.1	hypothetical protein	-
A6J82_RS00925	163197..163640	-	444	WP_024053143.1	DUF1492 domain-containing protein	-
A6J82_RS00930	163821..164222	-	402	Protein_157	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	160849..208978	48129

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7192.29 Da
• Isoelectric Point: 8.6749

>T74692 WP_003038349.1 NZ_CP020449:c161457-161266 [Streptococcus agalactiae]
MPLTGKEMAKLAEKNGWVEIRQNGSHHHFKHEDFDYIVTIPIHGNKDLGRGLESKILKDLGLK

Nucleotide

• Length: 192 bp

>T74692 NZ_CP020449:c161457-161266 [Streptococcus agalactiae]
ATGCCACTTACAGGGAAAGAAATGGCAAAGCTAGCCGAGAAAAACGGTTGGGTAGAAATCCGACAGAACGGCAGCCATCA
CCATTTCAAACATGAAGATTTTGATTATATAGTGACTATCCCAATCCATGGAAACAAGGATTTAGGAAGAGGGCTAGAAA
GCAAAATCCTGAAAGATTTGGGGCTGAAATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14164.17 Da
• Isoelectric Point: 4.5235

>AT74692 WP_041326065.1 NZ_CP020449:c161229-160849 [Streptococcus agalactiae]
MLKSYPAIFHKEEDGSYWVEFPEFGGGTQGANVEEALKNAREMLESVLAAYIDEGLDMPKPSDIMALTVKDGFVSMIQAD
PTPFIRNNKAIRKNVTVPEWLVRLADREKVNYSEVLTQALETKLQA

Nucleotide

• Length: 381 bp

>AT74692 NZ_CP020449:c161229-160849 [Streptococcus agalactiae]
ATGTTAAAATCATATCCAGCAATTTTTCATAAAGAGGAAGACGGTTCTTATTGGGTAGAATTTCCAGAGTTTGGAGGAGG
CACACAAGGGGCAAATGTTGAAGAAGCCTTGAAAAATGCCCGTGAAATGCTTGAGAGTGTTTTAGCTGCTTACATAGACG
AAGGATTAGATATGCCAAAGCCTAGCGACATCATGGCTTTAACCGTTAAAGACGGCTTTGTTAGCATGATACAAGCAGAC
CCTACCCCGTTTATTCGCAACAATAAAGCCATTAGAAAGAATGTGACTGTCCCTGAATGGTTAGTAAGATTAGCGGATCG
TGAAAAAGTAAATTATTCTGAAGTGCTAACTCAAGCCCTAGAAACAAAATTACAAGCCTAG

Structures

Toxin

• AlphaFold DB: I0S7M8