Detailed information of TA system TA074691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 92308..92920
• Replicon: chromosome
• Accession: NZ_CP020449
• Organism: Streptococcus agalactiae strain FDAARGOS_254

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: A6J82_RS00545
• Protein ID: WP_000384859.1
• Coordinates: 92585..92920 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: A6J82_RS00540
• Protein ID: WP_000259017.1
• Coordinates: 92308..92595 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J82_RS00510	88609..88890	-	282	WP_000052403.1	hypothetical protein	-
A6J82_RS00515	88924..89310	-	387	WP_000259071.1	hypothetical protein	-
A6J82_RS00520	89295..89975	-	681	WP_025194578.1	hypothetical protein	-
A6J82_RS00525	90509..90916	-	408	WP_000749954.1	hypothetical protein	-
A6J82_RS00530	91002..91409	-	408	WP_000749960.1	hypothetical protein	-
A6J82_RS00535	91511..91801	-	291	WP_000078284.1	WXG100 family type VII secretion target	-
A6J82_RS00540	92308..92595	+	288	WP_000259017.1	hypothetical protein	Antitoxin
A6J82_RS00545	92585..92920	+	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6J82_RS00550	93225..93695	-	471	WP_000130119.1	hypothetical protein	-
A6J82_RS00555	93863..95119	-	1257	WP_000122836.1	plasmid recombination protein	-
A6J82_RS00560	95436..95870	-	435	WP_001220479.1	hypothetical protein	-
A6J82_RS00565	95906..96781	-	876	WP_000421240.1	hypothetical protein	-
A6J82_RS00575	97081..97722	-	642	WP_000591144.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	92034..100890	8856

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T74691 WP_000384859.1 NZ_CP020449:92585-92920 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T74691 NZ_CP020449:92585-92920 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT74691 WP_000259017.1 NZ_CP020449:92308-92595 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT74691 NZ_CP020449:92308-92595 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6