Detailed information of TA system TA074690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 34284..34833
• Replicon: plasmid unnamed6
• Accession: NZ_CP020446
• Organism: Paracoccus yeei strain FDAARGOS_252

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: A6J80_RS22690
• Protein ID: WP_080623344.1
• Coordinates: 34284..34601 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0D5A1Q4
• Locus tag: A6J80_RS22695
• Protein ID: WP_036763148.1
• Coordinates: 34591..34833 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J80_RS22670	31250..32608	+	1359	WP_167553534.1	glycosyltransferase family 92 protein	-
A6J80_RS22675	32850..32999	-	150	WP_080623341.1	hypothetical protein	-
A6J80_RS22680	32963..33259	-	297	WP_080623342.1	transposase	-
A6J80_RS22685	33745..34287	-	543	WP_080623343.1	recombinase family protein	-
A6J80_RS22690	34284..34601	-	318	WP_080623344.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6J80_RS22695	34591..34833	-	243	WP_036763148.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
A6J80_RS22700	35163..36839	+	1677	WP_080623345.1	DDE-type integrase/transposase/recombinase	-
A6J80_RS22705	36842..37750	+	909	WP_036734700.1	TniB family NTP-binding protein	-
A6J80_RS22710	37747..38868	+	1122	Protein_35	TniQ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..42744	42744

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-97)

Antitoxin

• Antitoxin ParD (6-78)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11756.52 Da
• Isoelectric Point: 5.5629

>T74690 WP_080623344.1 NZ_CP020446:c34601-34284 [Paracoccus yeei]
MTGELTGGVRLSPKAEADLEDIWRFGAAEWSPARADQYLDGLLAVFDLLLVMPGIARERTEFTPPVRIHPAGSHLVIYRT
GTDHLHILRVLGGRQDWLRLLEAIE

Nucleotide

• Length: 318 bp

>T74690 NZ_CP020446:c34601-34284 [Paracoccus yeei]
ATGACGGGTGAGCTGACCGGCGGCGTCAGGTTATCCCCGAAGGCCGAGGCTGACCTCGAGGACATCTGGCGCTTTGGCGC
AGCCGAGTGGTCCCCAGCCCGAGCCGATCAATATCTCGACGGGCTTCTTGCGGTTTTTGATCTCCTTCTTGTCATGCCGG
GGATTGCCCGGGAGCGAACAGAGTTTACCCCACCCGTGCGCATTCATCCGGCCGGATCCCACCTGGTGATCTACCGCACC
GGCACCGATCATCTGCATATCCTTCGCGTGCTCGGAGGACGACAGGACTGGCTGAGGCTCTTGGAGGCGATCGAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9047.11 Da
• Isoelectric Point: 8.6401

>AT74690 WP_036763148.1 NZ_CP020446:c34833-34591 [Paracoccus yeei]
MATMNVSLPDPMKSWVEERTRDGSYSNASDYVRHLIRRDQERARAIAQLQAAITEGLESGPPQPFDATGFKARMRRTHDG

Nucleotide

• Length: 243 bp

>AT74690 NZ_CP020446:c34833-34591 [Paracoccus yeei]
ATGGCGACGATGAACGTTTCTCTTCCCGATCCCATGAAGTCCTGGGTGGAGGAGCGCACCCGCGACGGAAGCTATAGCAA
CGCCAGCGATTACGTGCGCCACCTGATCCGCCGCGACCAGGAGCGGGCACGCGCCATCGCACAGTTGCAGGCCGCCATCA
CCGAAGGCTTGGAGAGCGGCCCACCCCAGCCCTTCGATGCCACAGGCTTCAAGGCCCGGATGCGCCGCACCCATGACGGG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0D5A1Q4