Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 44235..44797 Replicon plasmid unnamed4
Accession NZ_CP020444
Organism Paracoccus yeei strain FDAARGOS_252

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag A6J80_RS21165 Protein ID WP_080623105.1
Coordinates 44235..44528 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag A6J80_RS21170 Protein ID WP_080623106.1
Coordinates 44516..44797 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J80_RS21140 39639..40262 + 624 WP_080623100.1 hypothetical protein -
A6J80_RS21145 40259..40735 + 477 WP_080623101.1 signal peptidase II -
A6J80_RS21150 40781..41233 - 453 WP_080623102.1 manganese-binding transcriptional regulator MntR -
A6J80_RS21155 41332..42654 + 1323 WP_080623103.1 Nramp family divalent metal transporter -
A6J80_RS21160 42820..43905 - 1086 WP_080623104.1 DUF475 domain-containing protein -
A6J80_RS21165 44235..44528 - 294 WP_080623105.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J80_RS21170 44516..44797 - 282 WP_080623106.1 ribbon-helix-helix protein, CopG family Antitoxin
A6J80_RS21175 45226..46659 - 1434 WP_080623203.1 IS1182 family transposase -
A6J80_RS21180 46887..47345 + 459 WP_105291579.1 transposase -
A6J80_RS21185 47345..47698 + 354 WP_080622379.1 IS66 family insertion sequence element accessory protein TnpB -
A6J80_RS21190 47767..49332 + 1566 WP_080622378.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188526 188526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-43)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10969.67 Da        Isoelectric Point: 8.0181

>T74688 WP_080623105.1 NZ_CP020444:c44528-44235 [Paracoccus yeei]
MPQLIWTPEALQGVQRCYRFLAPKNLEAAARAVRAIREGMQIVSAHPGVGRPADKMEPAFREWLIPFGDSGYVVLYRVDD
DLAVVLAVRHQREAGYY

Download         Length: 294 bp

>T74688 NZ_CP020444:c44528-44235 [Paracoccus yeei]
ATGCCACAACTGATCTGGACACCAGAGGCGCTACAGGGTGTCCAGCGATGTTATCGCTTTCTTGCGCCGAAGAACCTTGA
AGCGGCAGCCCGTGCCGTGCGCGCAATCCGCGAGGGGATGCAGATCGTGTCCGCGCATCCGGGAGTCGGTCGTCCGGCCG
ACAAGATGGAGCCGGCTTTTCGGGAATGGTTGATCCCGTTCGGGGATAGCGGCTATGTCGTTCTTTACCGTGTCGATGAT
GATCTGGCCGTTGTTCTGGCAGTCAGGCATCAGCGCGAAGCCGGGTATTATTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10609.80 Da        Isoelectric Point: 5.8328

>AT74688 WP_080623106.1 NZ_CP020444:c44797-44516 [Paracoccus yeei]
MPAHPVAVKLDADVHARVRELAKAQHRSPHYLMREAIAQYVEREEKREAFRQEALTAWATYQGSGLHVTHTEADDWLAQL
EAGQDVEPPECHN

Download         Length: 282 bp

>AT74688 NZ_CP020444:c44797-44516 [Paracoccus yeei]
ATGCCTGCCCACCCTGTCGCTGTGAAGCTGGACGCAGATGTTCATGCCCGTGTGCGGGAGCTTGCCAAGGCACAACACCG
TTCTCCCCATTACCTGATGCGTGAAGCTATTGCCCAATACGTCGAGCGCGAAGAAAAGCGCGAAGCATTCCGACAAGAGG
CTCTGACCGCTTGGGCGACCTATCAAGGTTCGGGCCTGCATGTGACACATACGGAGGCGGACGACTGGCTAGCGCAGCTT
GAGGCCGGGCAGGACGTGGAACCGCCTGAATGCCACAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References