Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 18139..18839 Replicon plasmid unnamed4
Accession NZ_CP020444
Organism Paracoccus yeei strain FDAARGOS_252

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A6J80_RS21020 Protein ID WP_080623079.1
Coordinates 18139..18582 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A6J80_RS21025 Protein ID WP_080623080.1
Coordinates 18579..18839 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J80_RS20995 13535..14260 + 726 WP_167553514.1 ABC transporter permease subunit -
A6J80_RS21000 14272..15036 + 765 WP_080623076.1 ABC transporter ATP-binding protein -
A6J80_RS21005 15036..15884 + 849 WP_080623077.1 ABC transporter permease subunit -
A6J80_RS21010 15909..16649 + 741 WP_080623078.1 SDR family oxidoreductase -
A6J80_RS21015 16969..17802 - 834 WP_080620377.1 IS5 family transposase -
A6J80_RS21020 18139..18582 - 444 WP_080623079.1 type II toxin-antitoxin system VapC family toxin Toxin
A6J80_RS21025 18579..18839 - 261 WP_080623080.1 antitoxin Antitoxin
A6J80_RS23755 19142..19324 + 183 WP_146113102.1 hypothetical protein -
A6J80_RS21030 19849..21126 - 1278 WP_080623081.1 cytochrome P450 -
A6J80_RS21035 21126..21635 - 510 WP_080623082.1 signal peptidase II -
A6J80_RS21040 21632..22459 - 828 WP_080623201.1 cation diffusion facilitator family transporter -
A6J80_RS21045 22570..23052 + 483 WP_080623083.1 helix-turn-helix domain-containing protein -
A6J80_RS21050 23012..23785 - 774 WP_080623084.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188526 188526
- flank IS/Tn - - 16969..17802 833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-47)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15712.94 Da        Isoelectric Point: 4.4798

>T74687 WP_080623079.1 NZ_CP020444:c18582-18139 [Paracoccus yeei]
VIHTLLDTNAVITLVGRRSPELLGQVEASEPGSLAISAIVAHELWYGAYRSQKVAFNLETLRLLFTDLVILDITPEDARV
AGEIRAELARAGTPIGPYDVLIAGQAKARGLILVTNNTGEFGRVAGLILEDWTIARPDVNGGTPEAD

Download         Length: 444 bp

>T74687 NZ_CP020444:c18582-18139 [Paracoccus yeei]
GTGATCCACACTCTGCTTGACACCAATGCGGTGATTACGCTTGTCGGCCGCCGCTCGCCCGAGTTGCTTGGCCAAGTCGA
GGCGTCCGAGCCCGGTTCGCTTGCCATTTCTGCCATCGTGGCACATGAATTGTGGTACGGCGCCTATCGCAGCCAGAAGG
TTGCCTTCAACCTGGAAACCCTGCGGCTGCTGTTCACCGATCTTGTGATCCTCGATATCACCCCCGAGGACGCGCGCGTT
GCGGGCGAAATCCGAGCAGAACTTGCCCGTGCCGGCACGCCCATCGGGCCATACGACGTTCTGATCGCCGGACAGGCCAA
GGCACGCGGACTGATATTGGTGACGAACAACACGGGTGAGTTTGGCCGCGTCGCCGGGCTGATACTGGAAGACTGGACGA
TCGCCCGCCCCGACGTCAACGGCGGCACGCCAGAGGCTGATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9756.98 Da        Isoelectric Point: 9.3406

>AT74687 WP_080623080.1 NZ_CP020444:c18839-18579 [Paracoccus yeei]
MSHIAKVFRSGNSQAVRLPKDFRLDASEVEISREGDALILRPKAADRRPWASLRAAVDRGLSKDFMDDCRDQPAQQNRTN
LDQLFS

Download         Length: 261 bp

>AT74687 NZ_CP020444:c18839-18579 [Paracoccus yeei]
ATGTCCCATATCGCCAAGGTGTTCCGGTCGGGCAATTCGCAGGCCGTCCGACTGCCCAAGGACTTTCGTCTGGATGCCAG
CGAGGTCGAGATCTCGCGCGAGGGTGACGCCCTGATCCTTCGACCGAAGGCAGCTGATAGGAGACCGTGGGCATCGCTCC
GGGCTGCCGTTGATCGTGGACTGAGCAAGGACTTTATGGACGACTGCCGAGATCAGCCCGCACAGCAGAACCGCACCAAT
CTTGACCAGCTGTTTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References