Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1690754..1691316 Replicon chromosome
Accession NZ_CP020442
Organism Paracoccus yeei strain FDAARGOS_252

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A6J80_RS10775 Protein ID WP_080621471.1
Coordinates 1690754..1691125 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A6J80_RS10780 Protein ID WP_080621472.1
Coordinates 1691122..1691316 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J80_RS10745 1685982..1686317 + 336 WP_080621459.1 DUF736 domain-containing protein -
A6J80_RS10750 1686321..1687139 + 819 WP_080621461.1 lytic transglycosylase domain-containing protein -
A6J80_RS10755 1687189..1687770 + 582 WP_080621463.1 hypothetical protein -
A6J80_RS10760 1687887..1688291 - 405 WP_080621465.1 DUF1801 domain-containing protein -
A6J80_RS10765 1688663..1690402 + 1740 WP_080621467.1 VirD2 family relaxase/mobilization nuclease -
A6J80_RS10770 1690408..1690737 - 330 WP_080621469.1 hypothetical protein -
A6J80_RS10775 1690754..1691125 - 372 WP_080621471.1 type II toxin-antitoxin system VapC family toxin Toxin
A6J80_RS10780 1691122..1691316 - 195 WP_080621472.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
A6J80_RS10785 1691522..1693546 + 2025 WP_080621474.1 conjugal transfer protein TraG -
A6J80_RS10790 1693550..1693975 + 426 WP_080621476.1 CopG family transcriptional regulator -
A6J80_RS10795 1694007..1694261 - 255 WP_080621477.1 DUF2274 domain-containing protein -
A6J80_RS10800 1694266..1695438 - 1173 WP_080621478.1 TrbI/VirB10 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aac(3)-Ih - 1643921..1793667 149746


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13074.23 Da        Isoelectric Point: 5.9538

>T74686 WP_080621471.1 NZ_CP020442:c1691125-1690754 [Paracoccus yeei]
VILVDTSIWIDHLRAVDAELAGLLNAGLVLAHPFVIGELALGSLKDRETVIAAMQGLPQAPTASHAEVMALIEARQLFSL
GIGYVDAHLIAATLLAPDTTLWTRDRRLSAAAARVGIQHVLPQ

Download         Length: 372 bp

>T74686 NZ_CP020442:c1691125-1690754 [Paracoccus yeei]
GTGATCCTCGTCGATACCTCGATCTGGATCGACCACCTGCGCGCGGTCGATGCGGAACTGGCCGGTCTGCTGAATGCCGG
GTTGGTGCTGGCGCATCCCTTCGTCATCGGCGAACTGGCGCTCGGCAGCCTCAAGGACCGGGAGACCGTCATCGCCGCGA
TGCAGGGCTTGCCGCAGGCCCCAACGGCCAGCCATGCCGAGGTCATGGCGCTGATCGAGGCGCGGCAGCTGTTCAGCCTC
GGCATCGGCTATGTCGATGCGCATCTGATCGCCGCGACCCTGCTCGCCCCCGACACCACGCTCTGGACCCGCGACCGGCG
GCTGAGCGCGGCGGCGGCACGAGTTGGTATTCAGCATGTCCTGCCACAATAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7029.14 Da        Isoelectric Point: 10.9487

>AT74686 WP_080621472.1 NZ_CP020442:c1691316-1691122 [Paracoccus yeei]
MRTTLNLDDELLRQAHDLTGIGEKAVLVREGLKALIERESARRLALLGGTDKRAAVAPRRQPAP

Download         Length: 195 bp

>AT74686 NZ_CP020442:c1691316-1691122 [Paracoccus yeei]
ATGCGCACGACCCTCAATCTCGACGACGAGTTGCTCCGGCAAGCCCATGACCTCACCGGCATCGGCGAGAAGGCCGTCCT
GGTGCGCGAGGGGCTGAAGGCTCTGATCGAGCGCGAGAGCGCCCGACGGCTCGCCCTGCTCGGCGGCACCGACAAGCGGG
CAGCGGTCGCCCCGCGCCGGCAGCCGGCGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References