Detailed information of TA system TA074682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 594184..595162
• Replicon: chromosome
• Accession: NZ_CP020437
• Organism: Bacillus sp. FDAARGOS_235

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: K0FNW8
• Locus tag: A6J74_RS04700
• Protein ID: WP_000155917.1
• Coordinates: 594422..595162 (-)
• Length: 247 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: J8KE32
• Locus tag: A6J74_RS04695
• Protein ID: WP_000588713.1
• Coordinates: 594184..594309 (-)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J74_RS04670	590031..590633	-	603	WP_000517300.1	hypothetical protein	-
A6J74_RS04675	590661..591470	-	810	WP_000678380.1	C39 family peptidase	-
A6J74_RS04680	591781..593250	-	1470	WP_000287565.1	beta-Ala-His dipeptidase	-
A6J74_RS04685	593494..593883	+	390	WP_000732294.1	YxeA family protein	-
A6J74_RS04690	593932..594108	-	177	WP_000808012.1	stage II sporulation protein SB	-
A6J74_RS04695	594184..594309	-	126	WP_000588713.1	hypothetical protein	Antitoxin
A6J74_RS04700	594422..595162	-	741	WP_000155917.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
A6J74_RS04710	595349..596086	-	738	WP_000594132.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
A6J74_RS04715	596254..596736	-	483	WP_000191892.1	MarR family winged helix-turn-helix transcriptional regulator	-
A6J74_RS04720	596863..598539	+	1677	WP_000857157.1	alpha-keto acid decarboxylase family protein	-
A6J74_RS04725	598720..599502	-	783	WP_000381781.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-244)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 247 a.a.
• Molecular weight: 28446.03 Da
• Isoelectric Point: 7.3946

>T74682 WP_000155917.1 NZ_CP020437:c595162-594422 [Bacillus sp. FDAARGOS_235]
MTISNIRIGLFILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK

Nucleotide

• Length: 741 bp

>T74682 NZ_CP020437:c595162-594422 [Bacillus sp. FDAARGOS_235]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTATGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATTAAAGGAATCGATTTAACCCTCTGGAAAAATTTATTAATGTTCACTGCGATGGTCATTTTCGTTGATATTTCA
TTTATTTTAACACCTAACATTTCGGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCTTCAAAAGCAAGAGGGGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAAATCGGAGCGAAA
ATTGTTGTATTTGAAGCAGCGAATGAATTAAATACGGGCTTTCGTGGTATTCGTTCTCAATTTAGTATTACAATACCTAT
AGAGCATATAGAGCAATTGAATGAACAAAAAGCAGTACAAGTAGAAAACGTGGGAATTATACCAGCAAAAATAATGAATG
ATGTTTTTATCGTTATTGATGGGAAGAAGAATAGCCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4951.43 Da
• Isoelectric Point: 4.1079

>AT74682 WP_000588713.1 NZ_CP020437:c594309-594184 [Bacillus sp. FDAARGOS_235]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK

Nucleotide

• Length: 126 bp

>AT74682 NZ_CP020437:c594309-594184 [Bacillus sp. FDAARGOS_235]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGAAAATGAAGATACAACAGATTTCTCTTTAATCAAAGGAGATAC
GTTGCAGCAAGTAGAAAAGTTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: K0FNW8

Antitoxin

• AlphaFold DB: J8KE32