Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1542816..1543471 Replicon chromosome
Accession NZ_CP020419
Organism Neisseria gonorrhoeae strain FDAARGOS_207

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag A6J46_RS08915 Protein ID WP_003691083.1
Coordinates 1542816..1543235 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag A6J46_RS08920 Protein ID WP_003688410.1
Coordinates 1543235..1543471 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J46_RS08895 1538050..1539591 - 1542 WP_003688418.1 multidrug efflux MFS transporter -
A6J46_RS08900 1539739..1540518 + 780 WP_003688416.1 (Fe-S)-binding protein -
A6J46_RS08905 1540515..1541216 + 702 WP_003688414.1 lactate utilization protein C -
A6J46_RS08910 1541213..1542667 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
A6J46_RS08915 1542816..1543235 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
A6J46_RS08920 1543235..1543471 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
A6J46_RS08925 1543677..1544498 - 822 WP_010358440.1 IS3 family transposase -
A6J46_RS08930 1544503..1544931 - 429 WP_080229245.1 helix-turn-helix domain-containing protein -
A6J46_RS08940 1545143..1545674 + 532 Protein_1556 IS110 family transposase -
A6J46_RS08945 1545912..1546802 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
A6J46_RS08950 1546813..1547979 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
A6J46_RS08955 1548051..1548338 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1545122..1545595 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T74667 WP_003691083.1 NZ_CP020419:c1543235-1542816 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T74667 NZ_CP020419:c1543235-1542816 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT74667 WP_003688410.1 NZ_CP020419:c1543471-1543235 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT74667 NZ_CP020419:c1543471-1543235 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References