Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1389830..1390485 Replicon chromosome
Accession NZ_CP020418
Organism Neisseria gonorrhoeae strain FDAARGOS_205

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag A6J44_RS08830 Protein ID WP_003691083.1
Coordinates 1390066..1390485 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A6J44_RS08825 Protein ID WP_082295416.1
Coordinates 1389830..1390066 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J44_RS08790 1384964..1385251 + 288 WP_003688407.1 hypothetical protein -
A6J44_RS08795 1385323..1386489 + 1167 WP_047919363.1 ADP-forming succinate--CoA ligase subunit beta -
A6J44_RS08800 1386500..1387390 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
A6J44_RS08805 1387773..1388159 - 387 Protein_1442 IS110 family transposase -
A6J44_RS08810 1388371..1388799 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
A6J44_RS08815 1388804..1389382 + 579 WP_003697246.1 IS3 family transposase -
A6J44_RS08820 1389427..1389624 + 198 WP_033910354.1 IS3 family transposase -
A6J44_RS08825 1389830..1390066 + 237 WP_082295416.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
A6J44_RS08830 1390066..1390485 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
A6J44_RS08835 1390634..1392088 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
A6J44_RS08840 1392085..1392786 - 702 WP_003688414.1 lactate utilization protein C -
A6J44_RS08845 1392783..1393562 - 780 WP_003688416.1 (Fe-S)-binding protein -
A6J44_RS08850 1393710..1395251 + 1542 WP_003688418.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T74665 WP_003691083.1 NZ_CP020418:1390066-1390485 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T74665 NZ_CP020418:1390066-1390485 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8380.52 Da        Isoelectric Point: 5.7904

>AT74665 WP_082295416.1 NZ_CP020418:1389830-1390066 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGCSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT74665 NZ_CP020418:1389830-1390066 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGTGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure

References