Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 25856..26541 | Replicon | chromosome |
| Accession | NZ_CP020418 | ||
| Organism | Neisseria gonorrhoeae strain FDAARGOS_205 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | A6J44_RS00475 | Protein ID | WP_003689143.1 |
| Coordinates | 26359..26541 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | A6J44_RS00470 | Protein ID | WP_003691454.1 |
| Coordinates | 25856..26257 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A6J44_RS00415 | 20912..21127 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| A6J44_RS00420 | 21179..21670 | - | 492 | WP_050159882.1 | siphovirus Gp157 family protein | - |
| A6J44_RS00425 | 21667..21849 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| A6J44_RS00430 | 21990..22676 | - | 687 | WP_010357532.1 | hypothetical protein | - |
| A6J44_RS00435 | 22745..22906 | - | 162 | WP_003702497.1 | hypothetical protein | - |
| A6J44_RS00440 | 22903..23178 | - | 276 | WP_105165760.1 | hypothetical protein | - |
| A6J44_RS00445 | 23331..23663 | - | 333 | WP_003687946.1 | hypothetical protein | - |
| A6J44_RS00450 | 23804..24079 | - | 276 | WP_003694994.1 | hypothetical protein | - |
| A6J44_RS00455 | 24076..24552 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| A6J44_RS00460 | 24585..24785 | - | 201 | WP_003692842.1 | hypothetical protein | - |
| A6J44_RS00465 | 24975..25757 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| A6J44_RS00470 | 25856..26257 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| A6J44_RS00475 | 26359..26541 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| A6J44_RS00480 | 26711..27529 | - | 819 | WP_025455900.1 | DUF3037 domain-containing protein | - |
| A6J44_RS00485 | 27526..28224 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| A6J44_RS00490 | 28463..29173 | - | 711 | WP_025455899.1 | helix-turn-helix transcriptional regulator | - |
| A6J44_RS00495 | 29289..29477 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| A6J44_RS00500 | 29557..29712 | + | 156 | WP_003689578.1 | hypothetical protein | - |
| A6J44_RS00505 | 29689..29877 | - | 189 | WP_003691445.1 | hypothetical protein | - |
| A6J44_RS00510 | 30050..30277 | + | 228 | WP_003691442.1 | helix-turn-helix domain-containing protein | - |
| A6J44_RS00515 | 30274..31284 | + | 1011 | WP_082295347.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 10684..43926 | 33242 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T74664 WP_003689143.1 NZ_CP020418:c26541-26359 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T74664 NZ_CP020418:c26541-26359 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT74664 WP_003691454.1 NZ_CP020418:c26257-25856 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT74664 NZ_CP020418:c26257-25856 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|