Detailed information of TA system TA074663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta(toxin)
• Location: 25279..26930
• Replicon: plasmid unnamed1
• Accession: NZ_CP020416
• Organism: Neisseria gonorrhoeae strain FDAARGOS_205

Toxin (Protein)

• Gene name: ng_zeta1
• Uniprot ID: -
• Locus tag: A6J44_RS00160
• Protein ID: WP_033911112.1
• Coordinates: 25279..26484 (+)
• Length: 402 a.a.

Antitoxin (Protein)

• Gene name: ng_epsilon1
• Uniprot ID: D5K9G8
• Locus tag: A6J44_RS00165
• Protein ID: WP_003701903.1
• Coordinates: 26499..26930 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J44_RS00125	20867..21235	+	369	WP_003701920.1	hypothetical protein	-
A6J44_RS00130	21219..21590	+	372	WP_003701919.1	hypothetical protein	-
A6J44_RS00135	21594..22490	+	897	WP_003701917.1	hypothetical protein	-
A6J44_RS00140	22642..23130	-	489	WP_014580055.1	hypothetical protein	-
A6J44_RS00145	23600..23848	+	249	WP_014580056.1	hypothetical protein	-
A6J44_RS00150	23845..25053	+	1209	WP_014580057.1	zeta toxin family protein	-
A6J44_RS00155	25087..25272	+	186	WP_014580058.1	hypothetical protein	-
A6J44_RS00160	25279..26484	+	1206	WP_033911112.1	zeta toxin family protein	Toxin
A6J44_RS00165	26499..26930	+	432	WP_003701903.1	hypothetical protein	Antitoxin
A6J44_RS00170	26982..27536	+	555	WP_003701901.1	recombinase family protein	-
A6J44_RS00175	27646..27936	-	291	WP_003701899.1	virulence factor	-
A6J44_RS00180	28039..28638	-	600	WP_003701898.1	TrbN protein	-
A6J44_RS00185	28638..29216	-	579	WP_033911116.1	TrbM protein	-
A6J44_RS00190	29203..30831	-	1629	WP_047920931.1	P-type conjugative transfer protein TrbL	-
A6J44_RS00195	31045..31821	-	777	WP_003701891.1	P-type conjugative transfer protein TrbJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39053	39053

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• KfrB domain (284-343)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 402 a.a.
• Molecular weight: 44747.59 Da
• Isoelectric Point: 7.2930

>T74663 WP_033911112.1 NZ_CP020416:25279-26484 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGREASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R

Nucleotide

• Length: 1206 bp

>T74663 NZ_CP020416:25279-26484 [Neisseria gonorrhoeae]
ATGGTAAAACTGTCTAGCGATATTAATCTGAGAGATTTTGGCAATAACGAATATTTGTCTTCCGTTCAGGATGAGGCCAT
CCGTTTTGCGACCGAACAAACAGACGAGATATTGTCTTTATATAGCCAACATGCAGATACAGAAGGCGGTAGATATGTTT
GTGCTGATACGTTTAAAGAGTTGTTTCCAGCTTTTGAGAACAAAGAAGACAGGGCAACGGTTAATAATGCCATCCACAAT
TCAGCAGCAGTTTTATCTTCTACCCAGTTTGACGAGGTACTGAAACGCGACGAGCCACAGAAGAAAGAAGTTATTTTCGT
TACGGGAATTCCGGGTTCGGGAAAAACTTCGACAGTAAAAAACATGATGATGCAGGATACCACCAAGCTGCTTTTTGAAG
GACAGCTTGCACGGCCGCAGTCTGCTTTTCGCAAGATTGAGCAGTGTCTGGAGCGTAATCTTGAAGTTACTATCGTAGCC
GTCAGCATGAGGGCTGAAAGGGCTTCCGACAATACTTACAAACGGTTTAACGAATACGGCAGGGAAGCCAGTATAGGTAT
TATGGCTGATATTCAGGCCAATCTTCCTGACGGACTCAAGCAAATCAGGGATAAGTTTGGTGATGCGGTAAAAATTGTCG
GTATCAACCAAGACAGGAACAGTGAATTTATCGACAAGTTCGATGATGTCATCAAAATGCTTTCCTTGGGGTCGCAAGAG
CAAATATTGGGCAGGTTGGCCGAGAAAATCCAGAGCGACTTCGACTCAGGAAAAATCAGCCGGGAATGCTTCAATCAGGC
CAAGGGCAGTATGGATCTTGAAAGTGTTTTCGCCAAAAAAGAGTATTCCCAGCAAAGGGTAGTTACTAACTCCAAGGGTG
TTACCCTAGAAACAAAGTCAGCAAACGAGTTGTGGTCTAAGGTGGAACAAATTCCTGTAACAGGCATGAAAGCCGGTATC
TATTTACTAGGTCAAGCTAAAAAAGCAGAGACTGGTCAAACTTATTCCGGAGAAATCATTTACAAGGATGCCGCTGCGGT
ATTTCAAAAAACCAAAAACGGGCTTGTCAGGCACAATGCAACACATAACGAAGAAAGACTGGCCAAATTGGTTGAGATAG
GGCAGAACGTTTCTATCGGAAGCAATAAGGGCAAATTGATTGTCAAGTCTTTGGAGTATTCCGCCAAAAAATCCATCAGC
AGATAA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15927.05 Da
• Isoelectric Point: 4.4211

>AT74663 WP_003701903.1 NZ_CP020416:26499-26930 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ

Nucleotide

• Length: 432 bp

>AT74663 NZ_CP020416:26499-26930 [Neisseria gonorrhoeae]
ATGAAAGAAAAAATGCGGTTGATCACGGAAATTTCGCTGATTATCAGGGAACTGTCTTATTCCCGGCGCGGGTATCGGCC
TGAGAGTTATGCGGCTGCGCTGGATAATTTGACGATAATCGGAGATTTGGCCGACATTTTGCACAACATCGAGGCAGCGA
CAGGCAATCCATTTGTTCAAAGGATGGTTGATGAAAAACTGAGAAAGTTTGTTACCGATTTTCCGGCTTATAAGGTACGG
TTGTCTCCGTTTTTGAATGGCTGTCCCCATGACCTTTCGTTAGGAGCAGAATCGTTGGGTAAGGGGGAGAGTATCGCTGA
TGCCTTGGCCGTTCCTCCGGAAGAGGTAGATATTGCAGACATTGAGTTTGACCGTGTGCTTATCGAAGACGACCGTTGGA
CAGGAGCATATGATGGTGGTAACGCGCAATGA

Structures

Antitoxin

• AlphaFold DB: D5K9G8