Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1219892..1220547 Replicon chromosome
Accession NZ_CP020415
Organism Neisseria gonorrhoeae strain FDAARGOS_204

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag A6J43_RS06960 Protein ID WP_003691083.1
Coordinates 1219892..1220311 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag A6J43_RS06965 Protein ID WP_003688410.1
Coordinates 1220311..1220547 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J43_RS06940 1215126..1216667 - 1542 WP_003697015.1 multidrug efflux MFS transporter -
A6J43_RS06945 1216815..1217594 + 780 WP_003688416.1 (Fe-S)-binding protein -
A6J43_RS06950 1217591..1218292 + 702 WP_003688414.1 lactate utilization protein C -
A6J43_RS06955 1218289..1219743 + 1455 WP_082277570.1 iron-sulfur cluster-binding protein -
A6J43_RS06960 1219892..1220311 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
A6J43_RS06965 1220311..1220547 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
A6J43_RS06970 1220753..1220950 - 198 WP_033910354.1 IS3 family transposase -
A6J43_RS06975 1220995..1221573 - 579 WP_003697246.1 IS3 family transposase -
A6J43_RS06980 1221578..1222006 - 429 WP_080229245.1 helix-turn-helix domain-containing protein -
A6J43_RS06990 1222218..1222604 + 387 Protein_1215 IS110 family transposase -
A6J43_RS06995 1222987..1223877 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
A6J43_RS07000 1223888..1225054 - 1167 WP_003693287.1 ADP-forming succinate--CoA ligase subunit beta -
A6J43_RS07005 1225126..1225413 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T74662 WP_003691083.1 NZ_CP020415:c1220311-1219892 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T74662 NZ_CP020415:c1220311-1219892 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT74662 WP_003688410.1 NZ_CP020415:c1220547-1220311 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT74662 NZ_CP020415:c1220547-1220311 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References