Detailed information of TA system TA074661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 220467..221153
• Replicon: chromosome
• Accession: NZ_CP020415
• Organism: Neisseria gonorrhoeae strain FDAARGOS_204

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: A6J43_RS01370
• Protein ID: WP_003689143.1
• Coordinates: 220467..220649 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: A6J43_RS01375
• Protein ID: WP_003691454.1
• Coordinates: 220752..221153 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J43_RS01335	216136..217200	-	1065	WP_003693470.1	hypothetical protein	-
A6J43_RS01340	217318..217545	-	228	WP_003698261.1	helix-turn-helix domain-containing protein	-
A6J43_RS01345	217718..217906	+	189	WP_003691445.1	hypothetical protein	-
A6J43_RS01350	217883..218038	-	156	WP_003689578.1	hypothetical protein	-
A6J43_RS01355	218127..218312	-	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
A6J43_RS01360	218449..219204	+	756	WP_003693472.1	LexA family transcriptional regulator	-
A6J43_RS01365	219479..220297	+	819	WP_082277469.1	DUF3037 domain-containing protein	-
A6J43_RS01370	220467..220649	+	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
A6J43_RS01375	220752..221153	+	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A6J43_RS01380	221335..221919	+	585	WP_003693477.1	SocA family protein	-
A6J43_RS01385	221928..222344	+	417	WP_003693479.1	hypothetical protein	-
A6J43_RS01395	222919..223251	+	333	WP_105183567.1	hypothetical protein	-
A6J43_RS01400	223404..223679	+	276	WP_082277470.1	hypothetical protein	-
A6J43_RS01405	223676..223837	+	162	WP_003693867.1	hypothetical protein	-
A6J43_RS01410	223906..224592	+	687	WP_033910330.1	hypothetical protein	-
A6J43_RS01415	224732..224914	+	183	WP_003691535.1	hypothetical protein	-
A6J43_RS01420	224911..225402	+	492	WP_082277471.1	siphovirus Gp157 family protein	-
A6J43_RS01425	225454..225669	+	216	WP_003691538.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	202105..236659	34554

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T74661 WP_003689143.1 NZ_CP020415:220467-220649 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T74661 NZ_CP020415:220467-220649 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT74661 WP_003691454.1 NZ_CP020415:220752-221153 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT74661 NZ_CP020415:220752-221153 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2